Objective: To discuss the dose-effect relationship of maxingshigan decotion (MXSGD) in anti-asthmatic effects

and reveal characteristics of dose-effect relationship of Chinese compound preliminarily. Method: The influences of the 9 dose groups of MXSGD on the histamine phosphate induced asthma in guinea pigs were recorded and analyzed by the biological signal collection system

its dose-response curve was drawn in a dose as abscissa

effect as ordinate and the dose-effect relationship of multiple linear regression analysis. Result: MXSGD 1.33

3.0

10.13 g·kg-1 could significantly prolong the incubation period of asthma (P<0.05)

the dose-effect relationship between the asthma incubation period of equationwas Y=86.31+1.2X-0.063X2;MXSGD could significantly shorten the duration of asthma (P<0.05 or P<0.01)

the dose-effect relationship equation asthma duration effect Y=13.99+0.44X-0.014X2. Conclusion: The dose-effect relationship of maxingshigan decotion in anti-asthmatic effects is a non-linear

with the increase of the dose

indexes of effect on asthma animal model is increased.