Objective: To study anti-inflammatory and analgesic effects of Shangzhongxia generic gout decoction (SGGD) on sodium urate induced acute gouty arthritis (GA). Method: 60 rats were randomly divided into six groups

the control group

the model group

indomethacin group

SGGD high dose group

middle dose group

low dose group (20

10

5 g·kg-1)

10 in each group. SGGD was given once each day for 7 days.1 h after the last administration

according to the classical method Coderre

in addition to the control group

and rats in the remaining five groups were injected ankle injection of sodium urate crystal solution to establish acute gouty arthritis model. The degree of joint swelling were measured the

Flow cytometry was used to detect the content of peripheral blood Th17 cells

ELISA was used to detect serum IL-17

IL-6. Result: SGGD inhibited sodium urate induced ankle pain

decreased the levels of Th17 in peripheral blood

in high dose group

Th17 cells (1.65±0.25) % was significantly lower than that in the model group (3.25±0.96) %. Th17 cell related inflammatory factor IL-17 (0.54±0.09) μg·L-1 was significantly lower than that in the model group (0.69±0.07) μg·L-1. Inflammatory IL-6 content was obviously lower than that in the model group (P<0.05). Conclusion: SGGD has better therapeutic effect on sodium urate gouty arthritis

the mechanism may be related to the decreasing Th17 cells and the level of inflammatory factors IL-17

IL-6.