To provide valuable reference for excipient research and development

review characterization methods and applications of the solid excipients physico-chemical parameters. The monographs and literatures in characterization methods of the solid excipients powder flow

melting temperature

viscosity

particle size and particle size distribution

optical rotation

crystallinity

crystal type were retrieved and consulted. The characterization and specific application in solid excipients research was analyzed and summarized. The physico-chemical parameters of solid excipients characterization were comprehensively considered or combined with a suitable choice of characterization methods

and tend to take advantage of new technologies and new ways to more fully and effectively characterize the physico-chemical parameters of the excipients. Joint use appropriate characterization of the physico-chemical parameters of the solid excipients could effectively control the quality of the excipients

and the solid excipients research and development to provide a reference.