WU Qing-guang, LIU Ming-ping, ZHAO Zhen-dong. Effect of Hujin Pill on Express of Collagen Ⅳ in Liver Fibrosis Rats[J]. Chinese journal of experimental traditional medical formulae, 2005, (4): 45-47.
WU Qing-guang, LIU Ming-ping, ZHAO Zhen-dong. Effect of Hujin Pill on Express of Collagen Ⅳ in Liver Fibrosis Rats[J]. Chinese journal of experimental traditional medical formulae, 2005, (4): 45-47. DOI: 10.13422/j.cnki.syfjx.2005.04.019.
Objective:To observe the effect of Hujin Pill on fibrous hyperplasia and express of collagen Ⅳ in liver fibrosis rats.Methods:Model of liver fibrosis were induced by subcutaneous injection of CCl4 and treated with Hujin Pill.The changes of fibrous hyperplasia and express of collagen Ⅳ of the rats’ liver were observed with Van Gieson stain and immunohistochemistry.Results:The fibrous hyperplasia of liver and the express of collagen Ⅳ in liver fibrosis rats’ model had been markedly increased than that of control group.However
Hujin Pill could restrain fibrous hyperplasia and express of collagen Ⅳ in liver fibrosis rats.Conclusion:Hujin Pill was effective in treatment of CCl4-induced liver fibrosis.