金樱子多糖的免疫活性研究

张庭廷; 聂刘旺; 刘爱民; 朱升学; 杨扬; 赵姗姗

doi:10.13422/j.cnki.syfjx.2005.04.022

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金樱子多糖的免疫活性研究

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- 金樱子多糖的免疫活性研究
- Studies on Immune Activities of Rosa Laevigata Michx Polysaccharide
- 中国实验方剂学杂志 2005年第4期页码：55-58
- 作者机构：
  
  1. 安徽师范大学生命科学学院
  2. 安徽师范大学生命科学学院安徽芜湖241000
- 作者简介：
- 基金信息：
  
  安徽省教委自然科学基金资助项目（No:2003kj161）;芜湖市生物药业开发应用项目（No.2003sy128）.
- DOI：10.13422/j.cnki.syfjx.2005.04.022
  中图分类号： R285.5
- 纸质出版日期：2005
- 稿件说明：
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[1]张庭廷,聂刘旺,刘爱民,朱升学,杨扬,赵姗姗.金樱子多糖的免疫活性研究[J].中国实验方剂学杂志,2005(04):55-58.

ZHANG Ting-ting, NIE Liu-wang, LIU Ai-min, et al. Studies on Immune Activities of Rosa Laevigata Michx Polysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2005, (4): 55-58.
[1]张庭廷,聂刘旺,刘爱民,朱升学,杨扬,赵姗姗.金樱子多糖的免疫活性研究[J].中国实验方剂学杂志,2005(04):55-58. DOI： 10.13422/j.cnki.syfjx.2005.04.022.

ZHANG Ting-ting, NIE Liu-wang, LIU Ai-min, et al. Studies on Immune Activities of Rosa Laevigata Michx Polysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2005, (4): 55-58. DOI： 10.13422/j.cnki.syfjx.2005.04.022.

摘要

目的:探索金樱子多糖（RP）的免疫活性。方法:小鼠igRP后

测定:1.巨噬细胞清除血中刚果红能力;2.对以鸡红细胞为抗原的溶血素生成的影响;3.对2

4二硝基氟苯所致迟发型超敏反应的影响;4.RP对卡介苗和脂多糖致免疫性肝损伤的保护作用。结果:1.一定浓度的RP可提高小鼠巨噬细胞对血中刚果红的吞噬能力;2.RP能增加小鼠溶血素的生成;3.RP能显著恢复免疫功能低下小鼠的DTH反应;4.RP可降低血中转氨酶活性

逆转肝、脾指数。结论:RP具有增强小鼠非特异性免疫、体液免疫和细胞免疫作用

还有免疫调节作用。

Abstract

Objective:To research the immune activities of Rosa laevigata michx polysaccharide（RP）.Methods:After feeding mouse with RP for several days to determine:1.Mouse MΦ’S ability of removing Congo Red from the blood.2.RP’s effect on haemolysin content in mouse body induced by chicken erythrocytes.3.RP’s effect on the delayed-type hypersensitivity（DTH）induced by 2

4-dinitrofluorobenzene.4.RP’s immune modulation effect on mouse liver immune injure induced by BCG and LPS.Results:1.RP（125mg-250mg/kg）has strong ability to enhance mouse M  to swallow Congo Red.Compared with normal control group

it could significantly reduce the content of Congo Red in mouse blood （p<0.001）.2.RP can significantly enhance the content of haemolysin in mouse body.3.RP can significantly enhance response of the DTH in normal mouse and recover response to DTH in cyclophosphamide（Cy）intoxicated mouse.4.RP has obvious immune modulation effect on mouse liver immune injure induced by BCG and LPS.

and reduce the content of ALT and AST in serum（p<0.01 and 0.001）.Besides

they all can reduce the liver and spleen index.Conclusion:RP can enhance the immune reaction in mouse and has immune modulation function.

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