AIM:Through the analysis of hepatic fibrosis indices and CHB patients’ HBV precore mutant in 1896 site

also by means of Traditional Chinese Medicine（TCM） Syndrome differentiation and western medicine diagnosis

and hepatic fibrosis indicator analysis

the distributive characteristics of TCM syndromes in patients and the pathogenesis were investigated so as to provide objective data with clinical Syndrome differentiation of TCM.METHODS: 140 CHB patients were divided into two groups

HBV precore mutant positive group（70 cases） and HBV precore mutant negative group（70 cases）

Besides

30 healthy donors were taken as the control group. The serial indices of liver fibrosis（including HA

PCⅢ

Ⅳ.C and LN）

and the HBV precore variant strains were tested. Patients in the study groups were categorized as six Syndromes according to TCM diagnostic theory. RESULTS: There existed significant distributive differences between the two study groups. The level of hepatic fibrosis indices was found higher in mutation positive group than in the negative and control group

and the level in the mutation negative group was higher than in the control group. In the mutation negative group

the severe hepatitis B patients had considerably higher level of HA

PCⅢ and Ⅳ.C than the medium patients had

and the level in the medium patients was markedly higher than in the mild patients. Similar results were seen with HA

PCⅢ

Ⅳ.C and LN level in mutation positive group concerning the severe

medium and mild patients. Conclusion:Blood Stasis Syndrome exists in different stages as one of the basic syndrome of CHB patients with precore mutation. The level of HA

PCⅢ

Ⅳ.C and LN level may be taken as one of the objective data in confirming Blood Stasis Syndrome.