LIU Min 1, 2, TAN Yu-qing1, et al. Effects of Different Combinations of Four Components in Guizhi Decoction on IL-1β Stimulated PGE2 Secretion of Cerebral Microvascular Endothelial Cell[J]. Chinese journal of experimental traditional medical formulae, 2005, (5): 59-61.
LIU Min 1, 2, TAN Yu-qing1, et al. Effects of Different Combinations of Four Components in Guizhi Decoction on IL-1β Stimulated PGE2 Secretion of Cerebral Microvascular Endothelial Cell[J]. Chinese journal of experimental traditional medical formulae, 2005, (5): 59-61. DOI: 10.13422/j.cnki.syfjx.2005.05.024.
Objective:To investigate the effects of different combinations of four components in Guizhi decoction on secretion of prostaglandin E
2
(PGE
2
) by interleukin-1β(IL-1β) stimulation in rats cerebral microvascular endothelial cell(rCMEC).These four components are among the extracted fractions of Guizhi Decoction.Methods:The amounts of PGE
2
were measured by radioimmunoassay method.Results:Twenty of the combinations significantly decreased the excessive secretion of PGE
2
induced by IL-1β in the supernatant of rCMEC.The results had the statistical signification.Conclusion:The above mentioned combinations might be the substance foundation of the Fr.A of the decoction in its dual-directional thermoregulation.