ZHAO Bao-sheng1, DONG Shu-yun2, HUO Hai-ru1, et al. Advances in the Animal Models for Non-insulin-dependent Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2005, (5): 62-66.
ZHAO Bao-sheng1, DONG Shu-yun2, HUO Hai-ru1, et al. Advances in the Animal Models for Non-insulin-dependent Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2005, (5): 62-66. DOI: 10.13422/j.cnki.syfjx.2005.05.025.
Objective:To introduce Some establishing methods to Non-insulin-dependent diabetes mellitus(NIDDM) animal model.Methods:The established methods and techniques for the NIDDM animal model are summarized.Results:The NIDDM animal model’s establishing methods can meanly be divided into four aspects:spontaneous NIDDM model
experimental NIDDM model
gene knock-out NIDDM model and anti-insulin cell model for NIDDM.Conclusion:There are advantages and disadvantages in the four aspects to establish the NIDDM animal model.The experimental NIDDM model becomes the most important and commonly used animal model to research NIDDM due to the low-cost
better maneuverability and the similar pathological process with that of human being.