复合因素致脾虚证模型大鼠血中胃肠激素含量的变化

王洪海; 谢鸣

doi:10.13422/j.cnki.syfjx.2006.10.016

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复合因素致脾虚证模型大鼠血中胃肠激素含量的变化

更新时间：2024-09-23

- 复合因素致脾虚证模型大鼠血中胃肠激素含量的变化
- Gastroenteric Hormones Content Changes of Blood in Model Rat of Spleen-qi Deficiency Made by Compound Factors
- 中国实验方剂学杂志 2006年第10期页码：31-35
- 作者机构：
  
  1. 北京中医药大学国家重点学科方剂学学科
  2. 北京中医药大学国家重点学科方剂学学科北京100029
- 作者简介：
- 基金信息：
  
  “211”基金资助项目
- DOI：10.13422/j.cnki.syfjx.2006.10.016
  中图分类号： R256.3
- 纸质出版日期：2006
- 稿件说明：
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[1]王洪海,谢鸣.复合因素致脾虚证模型大鼠血中胃肠激素含量的变化[J].中国实验方剂学杂志,2006(10):31-35.

WANG Hong-hai, XIE Ming~. Gastroenteric Hormones Content Changes of Blood in Model Rat of Spleen-qi Deficiency Made by Compound Factors[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 31-35.
[1]王洪海,谢鸣.复合因素致脾虚证模型大鼠血中胃肠激素含量的变化[J].中国实验方剂学杂志,2006(10):31-35. DOI： 10.13422/j.cnki.syfjx.2006.10.016.

WANG Hong-hai, XIE Ming~. Gastroenteric Hormones Content Changes of Blood in Model Rat of Spleen-qi Deficiency Made by Compound Factors[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 31-35. DOI： 10.13422/j.cnki.syfjx.2006.10.016.

摘要

目的:观察脾虚证模型大鼠造模不同时间点血中胃肠激素含量的变化。方法:采用游泳劳倦加饮食失节法

大鼠连续造模3w

自然恢复1w。结果:与对照组比较

模型大鼠在造模2

w出现明显饮食减少、大便溏薄、活动减少、倦卧拱背等改变;体重显著降低

第4w仍未见明显恢复;尿D-木糖排泄率在第2

4w均显著降低;血清胃泌素（GAS）和胃动素（MTL）水平第3w显著降低

自然恢复期显著升高;生长抑素水平于造模1w后明显降低

其余各点无明显变化;血管活性肠肽（VIP）水平2w时明显上升

第3w显著降低;P物质（SP）水平3w时显著降低;神经肽Y（NPY）水平于2

3w时明显降低

β-内啡肽（β-EP）水平于4w时明显降低。结论:该病因造模法造模3w可引起大鼠食少便溏、倦怠少动等表现

同时体重降低、尿D-木糖排泄率降低以及伴有多种胃肠激素的异常变化。

Abstract

Objective:To observe gastroenteric hormones content changes of blood in model rat of spleen-qi deficiency during different modelling time points.Methods:Adopting excess fatigue（by swimming） and out of constant diet on rats for constant three weeks and stopping doing on them in the 4w.Results:Compared with the control group

the model rats distinctly appear diet reduction

feces rarefaction

reduction activities

accidie and extrados

etc in modelling 2～3w;weight significantly failed

and it has yet to come back in the 4w;urine D-xylose excretion rate significantly falled during 2～4w;GAS and MTL level of serum failed in the 3w and significantly came back during natural recovery period;SS level markedly lower in the 1w

and no significant changes in the remaining time points;VIP level markedly rised in the 2w

and significantly failed in 3w;SP level clearly failed in the 3w;NPY level clearly lower in the 2～3w

and β-EP level clearly declined in the 4w.Conclusion:The model rat made by excess fatigue and out of constant diet for constant three weeks can appear diet reduction

feces rarefaction

reduction activities

etc;and abnormal changes of weight

urine D-xylose excretion rate

and gastroenteric hormones of Blood.

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