YANG Ming~1, FU Ping~1, CHEN Ying-li~1, et al. Approach of the Mechanism of Xiaogengyanjing Capsule Treat Menopausal Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 44-46.
YANG Ming~1, FU Ping~1, CHEN Ying-li~1, et al. Approach of the Mechanism of Xiaogengyanjing Capsule Treat Menopausal Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 44-46. DOI: 10.13422/j.cnki.syfjx.2006.10.020.
Objective:To discuss the mechanism of "Xiao Geng Yan Jing" capsule for treating menopausal syndrome.Methods:Extirpation of ovaries of rats was cartied out.After 30 days of oral administration
serum was collected to determine the contents of estradiol(E
The contents of 5-hydroxytryptamine(5-HT)、norepinephrine(NE)、dopamine(DA) and 5-hydroxyindoleacetic acid(5-HIAA) in brain was determined.The uterus was weighed.Results:The experiment showed that "Xiao Geng Yan Jing" capsule could decrease the levels of FSH and LH obviously
and increase the level of E
2
.For the brain of castrated rats
it could decrease 5-HT、5-HIAA contents and 5-HT/NE.But for NE、DA contents and 5-HIAA/5-HT it have no influence.Moreover
this medicine can increase the weight of the castrated rat and their uterus.Conclusion:"Xiao Geng Yah Jing" capsule can improve and treat menopausal syndrome though the mechanism of adjusting sexual gland and nervous function.