加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化的防治作用

宋崇顺; 任映; 尹军祥; 李本志; 孙海芸; 崔界蜂; 郭菁; 戴欣; 杨金铎; 谭玮

doi:10.13422/j.cnki.syfjx.2006.10.022

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加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化的防治作用

更新时间：2024-09-23

- 加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化的防治作用
- The Preventive and Therapeutic Effect of Jiaweibiejiajian Pill on Rats with Hepatic Fibrosis Induced by Serum Albumin
- 中国实验方剂学杂志 2006年第10期页码：51-53
- 作者机构：
  
  1. 北京中医药大学东直门医院
  2. 北京中医药大学东直门医院北京100700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2006.10.022
  中图分类号： R285.5
- 纸质出版日期：2006
- 稿件说明：
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[1]宋崇顺,任映,尹军祥,李本志,孙海芸,崔界蜂,郭菁,戴欣,杨金铎,谭玮.加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化的防治作用[J].中国实验方剂学杂志,2006(10):51-53.

SONG Chong-shun~, REN Ying, YIN Jun-xiang, et al. The Preventive and Therapeutic Effect of Jiaweibiejiajian Pill on Rats with Hepatic Fibrosis Induced by Serum Albumin[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 51-53.
[1]宋崇顺,任映,尹军祥,李本志,孙海芸,崔界蜂,郭菁,戴欣,杨金铎,谭玮.加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化的防治作用[J].中国实验方剂学杂志,2006(10):51-53. DOI： 10.13422/j.cnki.syfjx.2006.10.022.

SONG Chong-shun~, REN Ying, YIN Jun-xiang, et al. The Preventive and Therapeutic Effect of Jiaweibiejiajian Pill on Rats with Hepatic Fibrosis Induced by Serum Albumin[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 51-53. DOI： 10.13422/j.cnki.syfjx.2006.10.022.

摘要

目的:观察加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化的防治作用。方法:用人血清白蛋白给大鼠皮下注射免疫4次

在大鼠明显产生抗体后分组给药

再由尾静脉注射人血清白蛋白9次

可得到肝纤维化实验动物模型

实验结束后处死大鼠

收集血清

测定血清AST、ALT、TP、ALB、TBIL、A/C和CIV、LN、HA的含量。结果:同模型组相比

加味鳖甲煎丸能显著降低肝纤维化大鼠血清AST、ALT、TBIL、CIV、LN、HA含量;能显著增加TP、ALB含量和A/G比值

能显著改善大鼠肝纤维化程度。结论:加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化有较好的防治作用。

Abstract

Objective:To study the preventive and therapeutic effect of Chinese medicine Jiaweibiejiajian Pill（JWBJ）on rats with hepatic fibrosis induced by human serum albumin.Methods:The rats model with hepatic fibrosis was induced by multiple subcutaneous injections of serum albumin solution for 4 times.After it was confirmed that there were albumin antibody in rats serum

and then rats were divided into model-group

low-dose group of JWBJ

mediate-dose group of JWBJ and high-dose group of JWBJ.Rats were given JWBJ orally every day

and injected albumin solution into the rats caudal veins for 9 times during 4 weeks.When hepatic fibrosis was verified to come into being by pathological examination.Alanine amino transaminase（ALT）

aspartate aminotranferase（AST）

total protein（TP）

albumin（ALB） Hyaluronic acid（HA）

Laminin（LN）

Collagen Type（PC） in serum of all rats were examined.Results:Compared with the model group

JWBJ could obviously decrease the concentration of serum ALT

AST

CIV and increase the concentration of serum ALB

and increase the ratio of serum A/G of rats with hepatic fibrosis

and reduce the degree of hepatic fibrosis.Conclusion:JWBJ can effectively prevent and treat hepatic fibrosis induced by serum albumin.

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