Objective:To study the effects of polysaccharides in the grapefruit（GPs）on experimental mice with hyperlipidemia.Method:The water soluble polysaccharides of grapefruit were extracted in hot water

and isolated by ethanol.GPs were purified with Sephadex-50 column chromatography.The hyperlipidemia mice were fed with different doses of GPs to determine the mice serum lipids of control

GPs and model groups after two weeks feeding and to figure out atherosclerosis index（AI）.Result:The molecular weight of GPs were estimated to be（27 000） and（12 000） respectively.Compared with the model group

the concentrations of total cholesterol（TC）

total triglyeride（TG）

low density lipoprotein cholesterol（LDL-C） and AI in serum of GPs groups were decreased significantly（P<0.01）

and the concentration of high density lipoprotein cholesterol（HDL-C）in serum was obviously increased in the meantime（P<0.01）.Conclusion:The results implicate that the GPs have significantly effects in decreasing the blood lipid of hyperlipidemia and in preventing atherosclerosis.