Objective:To investigate the effects and mechanisms of Panax notoginseng（SQ） and Gynostemma pentaphyllum（JGL） on vascular remodeling.Methods:A total of sixity-four male New Zealand rabbits was randomly divided into six groups:Normal

Model

SQ

JGL

FF（SQ+JGL） and Captopril.The rabbits in control group were fed with regular diet

others were injected with bovine serum albumin 250 mg/kg and fed with high cholesterol diet

meanwhile

durgs were administrated orally.Rabbits were sacrificed at the end of 12 week

aortas serial crosssections were stained with hematoxylin-eosin and elastic fibers.Immunohistochemistry were performed to label PCNA and TGF-β1.Results:（1）The pathological changes of all drug treated groups were alleviated.（2）Compound prescription decreased the quantity of aorta VSMC nucleus compared with model group（P<0.05）.（3）The aorta PCNA immunostaining number and TGF-β1 immunostaining area of model group were significantly higher than normal group（P<0.01）

all drug treated groups decreased.Conclusion:Reduced expression of TGFβ1

and cellular proliferation may be related with inhibition of VR.