肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响

孙杰; 赵鸿亮; 王俊霞; 吴立文

doi:10.13422/j.cnki.syfjx.2007.09.020

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肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响

药理 | 更新时间：2024-09-23

- 肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响
- Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease
- 中国实验方剂学杂志 2007年第9期页码：37-40
- 作者机构：
  
  1. 甘肃中医学院
  2. 甘肃中医学院甘肃兰州730000
- 作者简介：
- 基金信息：
  
  甘肃省中医管理局（2004-GZK-07）
- DOI：10.13422/j.cnki.syfjx.2007.09.020
  中图分类号： R285.5
- 纸质出版日期：2007
- 稿件说明：
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[1]孙杰,赵鸿亮,王俊霞,吴立文.肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响[J].中国实验方剂学杂志,2007(09):37-40.

SUN Jie~, ZHAO Hong-liang, WANG Jun-xia, et al. Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, (9): 37-40.
[1]孙杰,赵鸿亮,王俊霞,吴立文.肺心通对慢性肺源性心脏病模型大鼠白介素8、肿瘤坏死因子α水平的影响[J].中国实验方剂学杂志,2007(09):37-40. DOI： 10.13422/j.cnki.syfjx.2007.09.020.

SUN Jie~, ZHAO Hong-liang, WANG Jun-xia, et al. Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, (9): 37-40. DOI： 10.13422/j.cnki.syfjx.2007.09.020.

摘要

目的:探讨肺心通对慢性肺源性心脏病（CPHD）模型大鼠的治疗效果及作用机理。方法:Wistar大鼠用野百合碱（MCT

60 mg.kg-1）1次腹腔注射复制CPHD大鼠模型

以肺心通混悬液治疗

21 d后

行支气管肺泡灌洗液（BALF）细胞总数及分类计数

测定大鼠血清、肺组织匀浆、肺泡灌洗液（BALF）中白介素8（IL-8）、肿瘤坏死因子α（TNF-α）的含量

肺组织切片在光镜、电镜下观察病理形态改变。结果:经治疗后

肺心通混悬液对上述检测指标的水平有明显抑制作用（P<0.01或P<0.05）

在光、电镜下观察对大鼠肺血管内皮细胞的损伤有一定的修复作用。结论:肺心通药物对CPHD大鼠有较好的治疗作用。

Abstract

Objective:To research the effect and the mechanism of Feixintong on rat model of chronic pulmonary heart disease（CPHD）.Methods:50 Wistar rats were randomly divided into five groups.Rats were given a single injection of monocrotaline（MCT

60 μg/g）to induce the model of CPHD.The Feixintong groups were treated by suspension in 21 days

then total white cell counts and differential counts and interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α）were examined.Lung organism slices were observed with microscope.Results:The examined items of the Feixintong groups were lower than the model groups（P<0.01 or P<0.05）

endotheliocytes were repaired by Feixintong.Conclusions:Feixintong has good efficacy for treatment of rat model of CPHD.

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