WANG Qiu-jing~1, LIU Jie~1, LIU Fen~1, et al. The Effect of Xue Fu Zhu Yu Granule on Cardial Oxygen Metabolism and Myocardial Infarction EECG in Dogs[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 24-26.
WANG Qiu-jing~1, LIU Jie~1, LIU Fen~1, et al. The Effect of Xue Fu Zhu Yu Granule on Cardial Oxygen Metabolism and Myocardial Infarction EECG in Dogs[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 24-26. DOI: 10.13422/j.cnki.syfjx.2007.11.008.
血府逐瘀颗粒对犬心肌氧代谢及急性心肌梗死心外膜电图的影响
摘要
目的:观察血府逐瘀颗粒(XFZHYG)对正常犬心肌氧代谢的影响
及对急性心肌梗死犬心外膜电图的影响。方法:将24只犬随机分为4组
每组各6只
第1组为生理盐水对照组
第2组为阳性对照药血府逐瘀口服液(XFZHYO)5.0 g.kg-1组
第3、4组分别为XFZHYG(2.5
5.0 g.kg-1)小、大剂量组。采用麻醉开胸犬
测定心肌氧代谢参数
并结扎犬左冠状动脉前降支(LAD)复制急性心肌梗死模型
测定心肌缺血程度(∑-ST)和缺血范围(N-ST)。结果:2.5
5.0 g.kg-1XFZHYG与生理盐水对照组比较
心肌耗氧量和心肌氧摄取率减少(P<0.05
P<0.01)心肌缺血程度和范围明显下降(P<0.05
P<0.01)。结论:XFZHYG能降低心肌耗氧量和心肌氧摄取率
对缺血心肌具有保护作用。
Abstract
Objective:To observe the effects of Xue Fu Zhu Yu Granule(XFZHYG) on cardial oxygen metabolism and its influmce on acute myocardial infarction EECG in anesthetic dogs.Methods:Twenty-four dogs were devided randomly in four groups: normal conrol group
positive control group
2.5 g·kg
-1
XFZHYG group;5.0 g·kg
-1
XFZHYG group.The cardial oxygen metabolism parameters were measured in the anaesthetiz dogs.The degree and range of myocardial ischemia
were determined by using the acute myocardial infarction model of ligation of left anterior descending(LAD) in the anaesthetized open-chest dogs.Results:Compared with normal control group
the cardial oxygen consumption decreased in 2.5 g·kg
-1
XFZHYG group and 5.0 g·kg
-1
XFZHYG group
the degree and range of myocardial ischemia also decreased.XFZHYG has protective effects on myocardial ischemia in dogs.Conclusion:XFZHYG can decrease cardial oxygen consumption in dogs.XFZHYG has protective effects on myocardial ischemia in dogs.