CHE Yan-zhong~. Effect and Relevant Mechanism of Jichuanjian on Gastrointestinal Peristalsis in Senile Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 44-46.
CHE Yan-zhong~. Effect and Relevant Mechanism of Jichuanjian on Gastrointestinal Peristalsis in Senile Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 44-46. DOI: 10.13422/j.cnki.syfjx.2007.11.014.
Objective:To investigate the effect of Jichuanjian on gastrointestinal peristalsis of senile rats and study relevant mechanism.Methods:The effect of Jichuanjian on gastrointestinal peristalsis of senile rats was observed by small intestine charcoal powder propelling test.The levels of motilin
substance P and somatostain in small intestine of rats were determinated by radioimmunoassay.Results:Different dosage of Jichuanjian can improve gastrointestinal peristalasis of senile rats and increase the levels of motilin
substance P
with reduce the content of somatostatin in small intestine of senile rats significantly.Conclusions:Jichuanjian can enhance the function of gastrointestinal peristalsis of senile rats by a mechanism of promoting secretion of motilin
substance P and lowering the level of somatostatin in intestine.