智脑胶囊对血管性痴呆模型大鼠行为学及脑组织NO、ET、CGRP含量的影响

杨文明; 王时光; 鲍远程; 杨兴涛; 张波; 汪美霞; 董婷

doi:10.13422/j.cnki.syfjx.2008.01.019

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智脑胶囊对血管性痴呆模型大鼠行为学及脑组织NO、ET、CGRP含量的影响

药理 | 更新时间：2024-09-23

- 智脑胶囊对血管性痴呆模型大鼠行为学及脑组织NO、ET、CGRP含量的影响
- The Effect of Zhinao Capsule on Behavior and the Content of NO、ET、CGRP in Brain Tissue of Rats with Vascular Dementia
- 中国实验方剂学杂志 2008年第1期页码：29-32
- 作者机构：
  
  1. 安徽中医学院第一附属医院
  2. 安徽中医学院第一附属医院安徽合肥230031
- 作者简介：
- 基金信息：
  
  安徽省教育厅自然科学基金（99JLZC138）;安徽省人才开发基金（2003Z026）;安徽省优秀青年科技基金（科金200203）
- DOI：10.13422/j.cnki.syfjx.2008.01.019
  中图分类号： R285
- 纸质出版日期：2008
- 稿件说明：
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[1]杨文明,王时光,鲍远程,杨兴涛,张波,汪美霞,董婷.智脑胶囊对血管性痴呆模型大鼠行为学及脑组织NO、ET、CGRP含量的影响[J].中国实验方剂学杂志,2008(01):29-32.

YANG Wen-ming, WANG Shi-guang, BAO Yuan-cheng, et al. The Effect of Zhinao Capsule on Behavior and the Content of NO、ET、CGRP in Brain Tissue of Rats with Vascular Dementia[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 29-32.
[1]杨文明,王时光,鲍远程,杨兴涛,张波,汪美霞,董婷.智脑胶囊对血管性痴呆模型大鼠行为学及脑组织NO、ET、CGRP含量的影响[J].中国实验方剂学杂志,2008(01):29-32. DOI： 10.13422/j.cnki.syfjx.2008.01.019.

YANG Wen-ming, WANG Shi-guang, BAO Yuan-cheng, et al. The Effect of Zhinao Capsule on Behavior and the Content of NO、ET、CGRP in Brain Tissue of Rats with Vascular Dementia[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 29-32. DOI： 10.13422/j.cnki.syfjx.2008.01.019.

摘要

目的:研究智脑胶囊对血管性痴呆（VD）模型大鼠学习记忆及脑组织NO、ET、CGRP含量的影响。方法:反复夹闭双侧颈总动脉（CCA）结合腹腔注射硝普钠制备拟血管性痴呆大鼠模型

检测大鼠学习记忆能力及脑组织中NO、ET、CGRP含量。结果:与模型组相比

智脑胶囊3剂量组能明显改善实验性VD模型大鼠学习记忆能力;智脑胶囊中、高剂量组、脑复康组、尼莫地平组脑组织中NO含量明显减少;智脑胶囊3个剂量组、脑复康组、尼莫地平组均能够明显降低ET含量

增加CGRP含量。智脑胶囊高剂量降低ET和增加CGRP含量的作用明显优于脑复康

也明显优于智脑胶囊中、低剂量组。结论:智脑胶囊可改善实验性血管性痴呆大鼠学习记忆障碍

其机制与降低实验性VD模型大鼠脑组织中NO、ET含量

提高CGRP含量有关。

Abstract

Objective:To investigate the effect of Zhinao Capsule on behavior and the content of Nitric Oxide（NO）

Endothelin（ET）

Calcitonin gene related peptide（CGRP） in brain tissue of rats with vascular dementia.Methods:After intraperitoneal injection of low dose of sodium nitroprusside

animal models of vascular dementia were established by clamping common carotid arteries repeatedly.Their learning and memory ability and the content of NO

CGRP of brain tissue were detected.Results:Compared with model group

three doses of Zhinao Capsule treated group could improve the ability of learning and memory obviously;The middle and high dose of Zhinao Capsule treated group

piracetam treated group and nimodipine treated group could significantly decrease the content of NO;Zhinao Capsule treated group

piracetam treated group and nimodipine treated group could significantly decrease the content of ET and improve the content of CGRP.High dose of Zhinao Capsule could decrease the content of ET and the content of CGRP

which was more significant than the piracetam treated group and the middle and low dose of Zhinao Capsule treated group.Conclusions:Zhinao Capsule could improve the learning and memory ability in rats with vascular dementia

which may be related to decreasing the content of NO and ET and increasing the content of CGRP of brain tissue in rats with vascular dementia.

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