加味四逆散对慢性应激模型大鼠下丘脑单胺类神经递质的影响

谢忠礼; 李杰; 王兴华

doi:10.13422/j.cnki.syfjx.2008.01.023

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加味四逆散对慢性应激模型大鼠下丘脑单胺类神经递质的影响

药理 | 更新时间：2024-09-23

- 加味四逆散对慢性应激模型大鼠下丘脑单胺类神经递质的影响
- The Effect of Jiawei Sini Powder on Monoamine Neurotransmitter of Hypothalamus in Rat Chronic Stress Model
- 中国实验方剂学杂志 2008年第1期页码：50-52
- 作者机构：
  
  1. 河南中医学院
  2. 南京中医药大学
- 作者简介：
- 基金信息：
  
  河南中医学院博士科研启动基金（No:03301027）
- DOI：10.13422/j.cnki.syfjx.2008.01.023
  中图分类号： R285
- 纸质出版日期：2008
- 稿件说明：
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[1]谢忠礼,李杰,王兴华.加味四逆散对慢性应激模型大鼠下丘脑单胺类神经递质的影响[J].中国实验方剂学杂志,2008(01):50-52.

XIE Zhong-li~. The Effect of Jiawei Sini Powder on Monoamine Neurotransmitter of Hypothalamus in Rat Chronic Stress Model[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 50-52.
[1]谢忠礼,李杰,王兴华.加味四逆散对慢性应激模型大鼠下丘脑单胺类神经递质的影响[J].中国实验方剂学杂志,2008(01):50-52. DOI： 10.13422/j.cnki.syfjx.2008.01.023.

XIE Zhong-li~. The Effect of Jiawei Sini Powder on Monoamine Neurotransmitter of Hypothalamus in Rat Chronic Stress Model[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 50-52. DOI： 10.13422/j.cnki.syfjx.2008.01.023.

摘要

目的:观察加味四逆散对慢性应激模型大鼠下丘脑单胺类神经递质的影响。方法:选择OPEN-FIELD法评分相近的40只成年SD雄性大鼠随机分为对照组、模型组、氟西汀组、加味四逆散小剂量组和加味四逆散大剂量组

每组各8只。应用分养和长期不可预见的中等强度应激造成大鼠慢性应激抑郁状态。以HPLC-EC法对照研究大鼠下丘脑单胺类神经递质的改变。结果:与对照组比

模型组大鼠下丘脑NE升高

5-HIAA和5-HT降低。与模型组比

氟西汀组、加味四逆散组NE降低而5-HIAA和5-HT升高。结论:慢性应激模型大鼠下丘脑单胺能神经功能活动失常

以去甲肾上腺素的升高和5-羟色胺的下降为主

加味四逆散的作用机理可能与平衡下丘脑单胺能神经的功能状态有关。

Abstract

Objective:To investigate the effect of Jiawei Sini Powder on monoamine transmitters of Hypothalamus of rat chronic stress model.Methods:Male Sprague-Dauley rats were randomly allocated to five groups as follows:control

model

fluoxetine

Jiawei Sini Powder with small dose and largt dose.The model was produced by sepration and chronic unpredictable mild stress.The behavior was detected by open-field test.HPLC-EC was used to study the changes of monoamine transmitters of Hypothalamus.Results:The results showed that NE level of model group is higher

and 5-HIAA and 5-HT are lower.Fluoxetine and Jiawei Sini Powder decreased the NE level and increased 5-HIAA and 5-HT.Conclusions:The data suggested that dysfanction of monoamine nerve of hypothalamus in rat chronic stress model is related with increased NE and decreased 5-HT

regulation for which may explain the mechanism of Jiawei Sini Powder.

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