Objective:To observe the change of CGRP after radiation by

192 Ir irradiation on spinal cord and to detect the protective action of Jingui Shenqi Wan for spinal cord damnification. Method:120 SD rats were randomly divided into four groups: model group

Jingui Shenqi Wan treatment group

prednisone positive group

and normal control group. Rats were given correspondence drug once a day for 14 days （normal control group and model group were given normal saline）. Then Animal models of radiation damage in spinal cord was induced in rats by

192 Ir interstitial irradiation

which was successfully created through the tube inserted in T

11 horizontal place in rat spinal cord by back-fixing technology. The dosage of model group

Jingiu Shenqi Wan treatment group and prednisone positive group was 22 Gy

the normal control group was free of irradiation. CGRP was tested by immunohistochemistry. Result: From the result of immunohistochemistry

we found the number and the brown substance in cells of spinal cord were significantly increased after irradiation. After treated with Jingui Shenqi Wan and prednisone

they were significantly decreased and weaked 8 h

24 h after brachytherapy（P

<

0.01）. However

there were no significantly difference compared with the model group 4 week after irradiation. Conclusion: It was found that CGRP regulated and controlled the process of rat spinal damnification. Jingui Shenqi Wan could relive the damnification spinal cord after brachytherapy in rats.