Objective:To study the effect of Tongmai（TMG） on experimental myocardial ischemia. Methods: By ranine vein injection pituitary creates rats myocardial ischemia（0.5 U·kg

-1 ）

to observe the effect of TMG on the J points’ change in rats ECG.; Choose the acute myocardial damage model in rats induced by Iso

to observe the J points’change in rats ECG. and the effect on lipid peroxidation after injecting Iso（sc 8 mg·kg

-1 ）; 0.8 mg·kg

-1 adrenalin was administrated by subcutaneous injection to establish rat blood stasis model; the formation of thrombus in vitro and the tolerance experiment of mouse under normal pressure. Results: TMG（9、4.5、2.3 g·kg

-1 ） remarkably restrained the change of J point in rat’s ECG after the injection of Pit

and obviously inhibited the state of J points’ descent in rats myocardial ischemia induced by Isoprenaline

reduce the level of MDA

advance the level of SOD; could inhibit the formation of thrombus in vitro; could reduce the blood viscosity in blood stasis model. TMG also can prolong the mouse’s survival time in hypoxia. Conclusions: TMG has protective action on acute experimental myocardial anoxia

and the effect is related to improve the hemorheology

inhibit the lipid peroxidation and the formation of thrombus

degrade oxygen consumption in cardiac muscle.