Objective:Through the anti-fatigue study of the decoction of Shengyang Yiqi to evaluate the therapeutic principle of removing and reinforcing on the anti-fatigue and to offer a new idea for anti-fatigue.Method:Ninety selected male mice（through swimming ability as preliminary screening） were divided randomly into 3 groups.They were blank control group

decotion of raising splen-yang to tonify stomach group

positive control group（spirulina）.The time of burden swimming

the increase of LA after 10 min swimming

the decreases of LA after 15 min rest after swimming

blood urea nitrogen

lactic acid dehydrogenase

hepatic glycogen

muscle glycogen were observed.Results:The results showed that decotion of Shengyang Yiqi could significantly enhance the exercise tolerance of mice

the time of swimming of the decotion group was longer than that of blank control group

the increase of LA after 10 min swimming of this recipe was lower than that of blank control group

the blood urea nitrogen level was also lower than that of blank control group.But this recipe has no effect on hepatic glycogen and muscle glycogen level.Conclusion:The decoction of Shengyang Yiqi has the effectiveness of anti-fatigue and fifteen days of application can demonstrate the anti-fatigue action to mice.