CHEN Liang-mian 1, WANG Jin-yu1, TONG Yan 1, et al. Advances in the Studies on In Situ Gels by Mucosal Drug Delivery[J]. Chinese journal of experimental traditional medical formulae, 2008, (8): 76-80.
CHEN Liang-mian 1, WANG Jin-yu1, TONG Yan 1, et al. Advances in the Studies on In Situ Gels by Mucosal Drug Delivery[J]. Chinese journal of experimental traditional medical formulae, 2008, (8): 76-80. DOI: 10.13422/j.cnki.syfjx.2008.08.033.
黏膜给药原位凝胶的研究进展
摘要
介绍了黏膜给药原位凝胶的优点、分类、常用聚合物
以及原位凝胶在各黏膜给药部位的应用情况。作为一种新型的药物传递系统
黏膜给药原位凝胶虽还存在一些技术难点有待攻克
但它结合了原位凝胶制剂和黏膜给药途径双重优势
是一个很有发展潜力的药物传递系统
尤其在中药新剂型的研究方面有着广阔的发展前景。
Abstract
The progress in the studies of temperature-sensitive
pH-dependent
ion-responsive in situ gels by mucosal drug delivery was reviwed and the applications of in situ gels in all mucosal parts were introduced.Although there were some technical problems remained in situ gel by combining the dosage form of in site gel with the route of mucosal administration
it was a novel drug delivery system with high developing potentials
especially in the study of dosage forms of traditional Chinese medicine.