Objective:To compare effects of Shenqi Fuzheng Injections prepared by two different crafts on the ability of reticuloendothelial system

the ability to restrain tumor and the protection to some important organs in S

180

-bearing mice.Methods: 42 tumor-bearing mice were randomly divided into five groups:the model group

the high dose group(8 g·kg

-1

)and the clinical equivalent dose group(4 g·kg

-1

) of Shenqi Fuzheng Injection on current craft

the high dose group(8 g·kg

-1

) and the clinical equivalent dose group(4 g·kg

-1

) of Shenqi Fuzheng Injection on previous craft.The model group was given physiological saline by intraperitoneal injection once a day

while the other groups were given different Shenqi Fuzheng Injections in the same way.Twelve days later

blood samples were collected from the mice and phagocytic index K was determined

Then the mice were sacrificed

the weights of body

tumor

spleen

liver and thymus gland were collected.Results:The weights of tumors and tamor indexes in four Shenqi Fuzheng Injection groups were lower than the model group

and the difference between groups of Shenqi Fuzheng Injection on current craft and the model group was significant（P

<

0.01～0.05）.However the groups of the current craft and the previous one had no significant difference;phagocytic index K in four Shenqi Fuzheng Injection groups were higher than that in the model group

and the difference between groups of Shenqi Fuzheng Injection on current craft and the model groups was significant（P

<

0.01～0.05）;and in(4 g·kg

-1

) groups

the current group was better than the previous one（P

<

0.05）.The spleen indexes in four Shenqi Fuzheng Injection groups were higher than that in the model group（P

<

0.05）

the liver indexes and the thymus gland one have no significant difference.Conclusion:In clinical equivalent dose(4 g·kg

-1

)

the ability of reticuloendothelial system in Shenqi Fuzheng Injection on current craft was better than the model group and the previous craft group;Shenqi Fuzheng Injection on current crafts could restrain tumors and protect spleens.However

there was no difference between the current and previous crafts in these aspects.