五虎汤制剂及其有效部位群的药效学比较

迟天燕; 纪雪飞; 夏明钰; 李伟; 邱峰; 邹莉波

doi:10.13422/j.cnki.syfjx.2009.02.021

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五虎汤制剂及其有效部位群的药效学比较

药理 | 更新时间：2024-09-23

- 五虎汤制剂及其有效部位群的药效学比较
- The Pharmacodynamic Comparison between the Crude Product and the Effective Components of Wuhu Tang
- 中国实验方剂学杂志 2009年15卷第2期页码：61-63
- 作者机构：
  
  沈阳药科大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.02.021
  中图分类号： R285.5
- 纸质出版日期：2009
- 稿件说明：
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[1]迟天燕,纪雪飞,夏明钰,李伟,邱峰,邹莉波.五虎汤制剂及其有效部位群的药效学比较[J].中国实验方剂学杂志,2009,15(02):61-63.

CHI Tian-yan, JI Xue-fei, XIA Ming-yu, et al. The Pharmacodynamic Comparison between the Crude Product and the Effective Components of Wuhu Tang[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 61-63.
[1]迟天燕,纪雪飞,夏明钰,李伟,邱峰,邹莉波.五虎汤制剂及其有效部位群的药效学比较[J].中国实验方剂学杂志,2009,15(02):61-63. DOI： 10.13422/j.cnki.syfjx.2009.02.021.

CHI Tian-yan, JI Xue-fei, XIA Ming-yu, et al. The Pharmacodynamic Comparison between the Crude Product and the Effective Components of Wuhu Tang[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 61-63. DOI： 10.13422/j.cnki.syfjx.2009.02.021.

摘要

目的:对五虎汤制剂及其有效部位群的镇咳、平喘、化痰作用进行药效学比较。方法:采用二氧化硫引咳、枸橼酸引咳、组胺—乙酰胆碱引喘和气管酚红排泄实验进行研究。结果:二者能显著延长二氧化硫及枸橼酸引咳的潜伏期;能显著延长组胺-乙酰胆碱混合液喷雾所致豚鼠喘息发作的潜伏期。结论:有效部位群各剂量组的疗效与同剂量制剂组在止咳、平喘、化痰作用上基本相当。

Abstract

Objective: Our purpose was to compare the antitussive

antiasthmatic and expectorant effects betwen aqueous extract of Wuhu Tang complex prescription and the crude product.Methods: Sulfur dioxide induced cough

citric acid induced cough

histamine-acetylcholine induced asthma attacks in guinea pig and excretion of phenol red in the airway of mouse were used.Results: They both markedly prolonged the latent period of cough induced by sulfur dioxide and citric acid;significantly prolonged the latent period of asthmatia attact by mixture of histamine-acetylcholine in guinea pigs

and had the tendency to increase the secretion of phenol red from the airway in mice.Conclusion: The effective components of Wuhu Tang can reach the same pharmacological effects of the crude product for antitussive

antiasthmatic and expectorant effects.

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