Objective: To observe the anti-tumor effect of Phellinus Linteus and Coriolus Versicolor Capsules（PLCVC） in S

1

80 sarcoma and H

2

2 hepatoma animal models in mice.Methods: The sarcoma S

1

80 and hepatoma H

2

2 models were established in mice.After 12 days of treatment

the animals were killed

and the subcutaneous sarcoma were separated and weighted.The levels of vascular endothelial growth factor（VEGF）

CD4 and CD8 of S

1

80 tumor tissue were investigated by immunohistochemical method.KM mice were intraperitoneal injected with H

2

2 hepatoma cells

and treated with different experimental drugs.The survival time was observed and recorded

and life-prolongation rate was calculated.Result: PLCVC could inhibit the growth of S

1

80 and H

2

2 tumor

and inhibit the expression of VEGF

improve the expression of CD4 and CD8.The survival time of the mice treated by PLCVC were significantly longer than the untreated group.Conclusion: PLCVC can inhibit the growth of tumour

the mechanism is partially related to inhibiting angiogenesis and improving the immunological function.