Objective:to discuss the effect of Panax notoginoside（PNS） on the neurologic impairment and（ ） 2008-06-18（ 陈志刚

）Tel:（010）67689776;E-mail:zgchen01@sina.com inflammatory factors IL-6

MMP-9 of rats with acute intracerebral hemorrhage.Method:The SD rats were divided into 3 groups randomly: sham group

model group and Panax notoginoside group.An animal model of ICH was edtablished by injecting collagenase Ⅶ into the caudate nucleus

and then Zea longa score

ICH mortality and the contents of IL-6 and MMP-9 in rat brain were measured.Results:Longa score of PNS group are lower than that of model group at the 5

th

day after ICH model establishment（P

<

0.05）.The improvement of neurologic impairment of PNS group at the 5

th

day compared with the 1

st

day are greater than that of model group（P

<

0.01）.The ICH mortality rate between PNS group and the model group had no significant difference.The contents of IL-6 and MMP-9 in brain tissues around hematoma of model group were significantly elevated at the 48

th

hour（P

<

0.01 and P

<

0.05）

and continued to rise till the 7

th

day（P

<

0.05 and P

<

0.01）.The inhibitive effect of PNS on the expressions of IL-6（P

<

0.05）

MMP-9（P

<

0.05）in brain on the 7

th

day was obvious.Conclusion:Panax notoginoside can promote recovery of neurologic impairment after ICH. One of the mechanisms may be that PNS could effectively inhibit IL-6 and MMP9.