超微粉碎技术在枳术丸中的应用及其溶出影响研究

袁清照; 张水寒; 杨瑛; 吴璐; 蔡光先

doi:10.13422/j.cnki.syfjx.2009.09.035

您当前的位置：

首页 >

文章列表页 >

超微粉碎技术在枳术丸中的应用及其溶出影响研究

质量标准 | 更新时间：2024-09-23

- 超微粉碎技术在枳术丸中的应用及其溶出影响研究
- The Application of the Micronization Technology in Zhizhu-Pills and the Produced Impact of its Dissolution
- 中国实验方剂学杂志 2009年15卷第9期页码：10-13
- 作者机构：
  
  1. 湖南中医药大学
  2. 湖南省中医药研究院中药超微工程技术研究中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.09.035
  中图分类号： R286.0
- 纸质出版日期：2009
- 稿件说明：
移动端阅览
[1]袁清照,张水寒,杨瑛,吴璐,蔡光先.超微粉碎技术在枳术丸中的应用及其溶出影响研究[J].中国实验方剂学杂志,2009,15(09):10-13.

YUAN Qing-zhao~1, ZHANG Shui-han~2, YANG Ying~2, et al. The Application of the Micronization Technology in Zhizhu-Pills and the Produced Impact of its Dissolution[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(9): 10-13.
[1]袁清照,张水寒,杨瑛,吴璐,蔡光先.超微粉碎技术在枳术丸中的应用及其溶出影响研究[J].中国实验方剂学杂志,2009,15(09):10-13. DOI： 10.13422/j.cnki.syfjx.2009.09.035.

YUAN Qing-zhao~1, ZHANG Shui-han~2, YANG Ying~2, et al. The Application of the Micronization Technology in Zhizhu-Pills and the Produced Impact of its Dissolution[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(9): 10-13. DOI： 10.13422/j.cnki.syfjx.2009.09.035.

摘要

目的:对经微粉化制备的枳术丸与枳术丸进行显微、理化鉴别、溶出情况对比研究

探索超微粉碎对丸剂质量的影响。方法:采用TLC法鉴别枳实与白术、采用HPLC法测定枳术丸橙皮苷的体外溶出情况

并采用了Weibull分布模型进行溶出动力学模拟。结果:超微粉碎与普通粉碎后TLC无显著差别

经微粉化制备的枳术丸各时间点的有效成分溶出较普通丸剂快。结论:枳术丸经超微粉碎后橙皮苷溶出量增加

溶出速度明显提高。

Abstract

Objective:To search for the micronization impact to the pill preparation

we carry out a series of comparative study on the micro characteristic、TLC characteristic、dissolution results of Ultro-micro and Normal powder of Zhizhu pill.Method:Using Fructus Aurantii Immaturus and Rhizoma Atractylodis Macrocephalae

the TLC information can be identified.Taking Hesperidin as the index component

the dissolution character were compared.The Weibull distribution analysis system were also applied.Result:We can see the almost similar TLC characteristic in the two pills

however the significant differences can be identified in the dissolution study on the Ultro-micro and the normal pills.Obviously

the dissolution rate and the total quantity of Hesperidin in the ultro-micro pills were increaseed.Conclusion:The active component of the pills can not be destructed in the process of micronization.Moreover

this behavior truly increase the vitro-utilization of the preparation.

关键词

Keywords

references

浏览量

231

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

橙皮苷及其衍生物抗癌作用机制的研究进展

HPLC测定牛黄清胃丸中枳实所含4种黄酮类成分及其药材基原分析

基于光谱法的陈皮饮片标准汤剂指纹图谱分析