Objective:To investigate the pathogenetic role of poison in wilson’s disease.Methods: The understandings of poison from both Chinese traditional medicine and western medicine were collected

Damages to organism by poison

especially the pathogenetic role of poison in wilson’s disease

were discussed.Results: Poison is a common pathogenetic factor clinically and may cause damage to many organs.Wilson’s disease is a systemic disease which refers to multi-systems and organs

the accumulation of copper poison in the body is its pathophysiologic basis

and also the foundation of therapeutical method for disintoxicating.Conclusion: Poison plays a very important role in the pathogenetic factors for Wilson’s disease.The key pathogenesis of Wilson’s disease is the accumulation of copper poison in the body

and it cause the damage to the collaterals of liver

the collaterals of brain and the whole body’s collaterals.The direct disintoxication is an important method of treating Wilson’s disease.