牡丹皮炭及其止血活性部位对大鼠血小板聚集性及血栓素B<sub>2</sub>和6-酮-前列腺素F<sub>1α</sub>的影响

李娴; 张丽; 丁安伟

doi:10.13422/j.cnki.syfjx.2009.11.019

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牡丹皮炭及其止血活性部位对大鼠血小板聚集性及血栓素B₂和6-酮-前列腺素F_1α的影响

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- 牡丹皮炭及其止血活性部位对大鼠血小板聚集性及血栓素B₂和6-酮-前列腺素F_1α的影响
- Effects of Carbonized Cortex Moutan and the Main Hemostasia Active Fractions of Carbonized Cortex Moutan on Platelet Aggregation and TXB₂,6-keto-PGF_1α in Rat
- 中国实验方剂学杂志 2009年15卷第11期页码：41-43
- 作者机构：
  
  南京中医药大学江苏省方剂研究重点实验室
- 作者简介：
- 基金信息：
  
  国家“十一五”科技攻关项目（2006BAI09B006-02）;2008年江苏省研究生培养创新工程项目（CX08B-200Z）
- DOI：10.13422/j.cnki.syfjx.2009.11.019
  中图分类号： R285.5
- 纸质出版日期：2009
- 稿件说明：
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[1]李娴,张丽,丁安伟.牡丹皮炭及其止血活性部位对大鼠血小板聚集性及血栓素B_2和6-酮-前列腺素F_(1α)的影响[J].中国实验方剂学杂志,2009,15(11):41-43.

LI Xian, ZHANG Li, DING An-wei. Effects of Carbonized Cortex Moutan and the Main Hemostasia Active Fractions of Carbonized Cortex Moutan on Platelet Aggregation and TXB₂,6-keto-PGF_1α in Rat[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 41-43.
[1]李娴,张丽,丁安伟.牡丹皮炭及其止血活性部位对大鼠血小板聚集性及血栓素B_2和6-酮-前列腺素F_(1α)的影响[J].中国实验方剂学杂志,2009,15(11):41-43. DOI： 10.13422/j.cnki.syfjx.2009.11.019.

LI Xian, ZHANG Li, DING An-wei. Effects of Carbonized Cortex Moutan and the Main Hemostasia Active Fractions of Carbonized Cortex Moutan on Platelet Aggregation and TXB₂,6-keto-PGF_1α in Rat[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 41-43. DOI： 10.13422/j.cnki.syfjx.2009.11.019.

摘要

目的:研究牡丹皮炭及其止血活性部位对大鼠血小板聚集性及血栓素B2（TXB2）、6-酮-前列腺素F1α（6-keto-PGF1α）的影响。方法:以SD大鼠为研究对象

观察牡丹皮炭及其止血活性部位对ADP和胶原诱导的血小板聚集率及TXB2和6-keto-PGF1α的含量的影响。结果:牡丹皮炭及其鞣质部位均能提高ADP和胶原诱导的血小板聚集率

提高TXB2而下调6-keto-PGF1α的含量。结论:牡丹皮炭及其鞣质活性部位以及乙酸乙酯部位可能是通过调节TXB2

6-keto-PGF1α含量来增强血小板的聚集功能

发挥止血、凝血作用。

Abstract

Objective:To study the effects of carbonized cortex moutan on platelet aggregation and TXB

、6-keto-PGF

1α

in rats.Methods:SD rats were used for the research.The effects of carbonized cortex moutan and the main hemostasia active fractions of carbonized cortex moutan on platelet aggregation induced by ADP and collagen

TXB

and 6-keto-PGF

1α

in rats were obserred.Results:Carbonized cortex moutan and the main hemostasia active fractions of carbonized cortex moutan increased platelet aggregation induced by ADP and collagen

then increased the level of TXB

and decreased the level of 6-keto-PGF

1α

.Conclusion:The main hemostasia mechanism of carbonized cortex moutan and the main hemostasia active fractions of carbonized cortex moutan is to increase platelet aggregation by affecting the level of TXB

and 6-keto-PGF

1α

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牡丹皮炭及其止血活性部位对大鼠血小板聚集性及血栓素B2和6-酮-前列腺素F1α的影响

Effects of Carbonized Cortex Moutan and the Main Hemostasia Active Fractions of Carbonized Cortex Moutan on Platelet Aggregation and TXB2,6-keto-PGF1α in Rat

DOI：10.13422/j.cnki.syfjx.2009.11.019

摘要

Abstract

关键词

Keywords

references

牡丹皮炭及其止血活性部位对大鼠血小板聚集性及血栓素B₂和6-酮-前列腺素F_1α的影响

Effects of Carbonized Cortex Moutan and the Main Hemostasia Active Fractions of Carbonized Cortex Moutan on Platelet Aggregation and TXB₂,6-keto-PGF_1α in Rat