Objective:To study the effect of drugs of invigorating spleen

heat-clearing

eliminating stasis on QOUH in rat model of gastric ulcer.Methods:The rat model of gastric ulcer was constructed by injection of acetic acid.The rats were randomly divided into model group

ranitidine group

invigorating spleen group

heating-clearing group

eliminating stasis group

complex prescription group and normal control group.The ulcer index（UI）

regenerated mucosal thickness

lamina muscularis mucosal width and capsular broaden glandular organ quantity were observed by HE

and the levels of EGF and 6-keto-PGF

1α

were detected by ELISA.The expression of EGFR in the mucosa around the ulcer was detected by SABC kit immunohistochemical method.Results:Compared with Model group

the regenerated mucosal thickness

lamina muscularis mucosae defect extent

UI and capsular broaden glandular organ quantity in invigoraing spleen

heat-clearing

elimianting stasis and complex prescription treating groups were different significantly（P

<

0.01）.And the effect of complex prescription was better than ranitidine in different degree（P

<

0.05

or P

<

0.01）.Compared with ranitidine

invigorating spleen group

heating-clearing group

eliminating stasis increased the levels of 6-keto-PGF

1α

closed to the normal.Compared with model group and normal control group

the levels of EGF in serum in treating groups were increased significantly（P

<

0.01）.Positive expression of EGFR around ulcerative tissues in treating groups were strengthened obviously（P

<

0.05

or P

<

0.01）

and the effect of complex prescription was the best（P

<

0.01）.Conclusion:Drugs of invigorating spleen

heat-clearing and eliminating stasis can improve the QOUH and prevent from recurring by improving histological maturation and functional maturation of regenerative mucosa in GU rats.