补肾益气活血法对应激、老年小鼠学习与记忆及老化相关酶活性的影响

张秋华; 孙文静; 王丹; 马良祥

doi:10.13422/j.cnki.syfjx.2009.11.032

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补肾益气活血法对应激、老年小鼠学习与记忆及老化相关酶活性的影响

药理 | 更新时间：2024-09-23

- 补肾益气活血法对应激、老年小鼠学习与记忆及老化相关酶活性的影响
- The Effects of Replenishing Kidney-Invigorating Qi-Activating Blood on Stress,Learning,Memory and the Related Enzyme Activities in Aged Mice
- 中国实验方剂学杂志 2009年15卷第11期页码：82-85
- 作者机构：
  
  1. 辽宁中医药大学
  2. 沈阳市中医研究所
  3. 沈阳医学院何氏视觉科学学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.11.032
  中图分类号： R285.5
- 纸质出版日期：2009
- 稿件说明：
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[1]张秋华,孙文静,王丹,马良祥.补肾益气活血法对应激、老年小鼠学习与记忆及老化相关酶活性的影响[J].中国实验方剂学杂志,2009,15(11):82-85.

ZHANG Qiu-hua~1, SUN Wen-jing~2, WANG Dan~3, et al. The Effects of Replenishing Kidney-Invigorating Qi-Activating Blood on Stress,Learning,Memory and the Related Enzyme Activities in Aged Mice[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 82-85.
[1]张秋华,孙文静,王丹,马良祥.补肾益气活血法对应激、老年小鼠学习与记忆及老化相关酶活性的影响[J].中国实验方剂学杂志,2009,15(11):82-85. DOI： 10.13422/j.cnki.syfjx.2009.11.032.

ZHANG Qiu-hua~1, SUN Wen-jing~2, WANG Dan~3, et al. The Effects of Replenishing Kidney-Invigorating Qi-Activating Blood on Stress,Learning,Memory and the Related Enzyme Activities in Aged Mice[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 82-85. DOI： 10.13422/j.cnki.syfjx.2009.11.032.

摘要

目的:探讨补肾益气活血方-葆青康对应激、老年小鼠学习与记忆及相关酶活性的影响。方法:采用游泳实验、耐缺氧实验和耐高温实验观察葆青康对小鼠抗应激能力的提升作用;采用食饵法大迷宫法测定葆青康对中、老年小鼠学习与记忆的影响;采用McEwen法测定葆青康对中、老年小鼠脑中单胺氧化酶-B（MAO-B）活性的影响;采用TBA比色法、邻苯三酚自氧化法和DNBT法测定葆青康对老年小鼠肝丙二醛（MDA）含量

心、脑、肝和血中超氧化物歧化酶（SOD）活性和谷胱甘肽过氧化物酶（GSH-Px）活性的影响。结果:葆青康能延长小鼠游泳时间、增加常压缺氧小鼠存活时间和降低小鼠耐高温的死亡率

提高小鼠抗应激的能力;葆青康能增加中老年小鼠学习与记忆能力

降低中老年小鼠脑MAO-B活性

降低老年小鼠肝中MDA含量、提高老年小鼠心、脑、肝和血中SOD和GSH-Px活性。结论:葆青康具有抗应激和抗衰老作用。

Abstract

Objective:To explore the effects of Baoqingkang

a prescription for replenishing kidney

invigorating Qi and activating blood

on anti-stress ability

the learning and memory and the related enzyme activities in the aged mice.Methods:The various stress including fatigue resistance

normal hypoxia tolerance and heat resistance abilities assay was employed to evaluate the anti-stress ability of Baoqingkang;The baiting method was employed to measure the learning and memory of the aged mice;McEwen method was employed to measure cerebral MAOB activities of the middle age and the old age mice.TBA method

pyrogallol autoxidation method and DNBT method were employed to determine the liver MDA

SOD activities and GSH-Px activities in brain

liver

heart and whole blood of the aged mice

respectively.Results:Baoqingkang could prolonge the mouse swimming time

the survival time of hypobaric hypoxic mice

decrease the mortality in the heat resistance assay

increase the anti-stress ability of the mice.Baoqingkang could improve the learning and memory of the middle age and the aged mice

and decrease the liver MDA content for the aged mice

increase SOD and GSH-Px activities in brain

liver

heart and whole blood for the aged mice.Conclusion:Baoqingkang has anti-stress and anti-aging effect.

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