Objective:To observe the pulmonary protective effect and impacts of local chest radiotherapy in corpore levels of connective tissue growth factor（CTGF）and platelet-derived growth factor（PDGF） after Qingzaojiufei soup treatment in patients with advanced and mediate chest tumor.Methods: The patients with advanced-mediate chest tumors who were ready to local radiotherapy were randomly divided into treatment group and control group.Qinzaojiufei soup was taken for 6 months in the treatment group from the beginning of radiotherapy.The levels of plasma CTGF and PDGF were detected before and after radiotherapy.Clinical symptoms

high-resolution CT and pulmonary diffusing capacity were observed from 15th days after the beginning of radiotherapy.Results: There were significantly difference in the concentration of plasma CTGF and plasma PDGF（P<0.001）in control group compared with the treatment group after radiation therapy. There was statistically significant difference in CO diffusing capacity

acute radiation pneumonia and the incidence of pulmonary fibrosis in treament group compared with control group after the 5 months and 10 months radiotherapy（P<0.05）.Conclusion: Qinzaojiufei soup can inhibit over-liberation of plasma CTGF and PDGF induced by radiotherapy to reduce the deterioration of pulmonary diffusing capacity.