顶空毛细管气相色谱法同时测定酒石酸布托啡诺中的多种残留溶剂

宋晓光; 朱圣亮; 李语如; 闫占宽

doi:10.13422/j.cnki.syfjx.2009.11.043

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顶空毛细管气相色谱法同时测定酒石酸布托啡诺中的多种残留溶剂

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- 顶空毛细管气相色谱法同时测定酒石酸布托啡诺中的多种残留溶剂
- Simultaneous Determination of Six Residual Organic Solvents in Butorphanol Tartrate by Capillary Gas Chromatography with Headspace Sampling
- 中国实验方剂学杂志 2009年15卷第11期页码：23-25
- 作者机构：
  
  江苏恒瑞医药股份有限公司
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.11.043
  中图分类号： R927
- 纸质出版日期：2009
- 稿件说明：
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[1]宋晓光,朱圣亮,李语如,闫占宽.顶空毛细管气相色谱法同时测定酒石酸布托啡诺中的多种残留溶剂[J].中国实验方剂学杂志,2009,15(11):23-25.

SONG Xiao-guang, ZHU Sheng-liang, LI Yu-ru, et al. Simultaneous Determination of Six Residual Organic Solvents in Butorphanol Tartrate by Capillary Gas Chromatography with Headspace Sampling[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 23-25.
[1]宋晓光,朱圣亮,李语如,闫占宽.顶空毛细管气相色谱法同时测定酒石酸布托啡诺中的多种残留溶剂[J].中国实验方剂学杂志,2009,15(11):23-25. DOI： 10.13422/j.cnki.syfjx.2009.11.043.

SONG Xiao-guang, ZHU Sheng-liang, LI Yu-ru, et al. Simultaneous Determination of Six Residual Organic Solvents in Butorphanol Tartrate by Capillary Gas Chromatography with Headspace Sampling[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 23-25. DOI： 10.13422/j.cnki.syfjx.2009.11.043.

摘要

目的:建立了酒石酸布托啡诺中残留有机溶剂甲醇、丙酮、乙醚、二氯甲烷、氯仿、四氢呋喃的分离测定方法。方法:采用顶空毛细管气相色谱法

色谱柱为ZB-1

检测器为FID

水为溶解介质

乙酸乙酯为内标。结果:甲醇、丙酮、乙醚、二氯甲烷、氯仿、四氢呋喃的线性范围分别为1.811

94.6

1.015

89.4

0.130

07.2

0.447

98.3

1.776

00.6

0.341

01.8μg.mL-1;甲醇、丙酮、乙醚、二氯甲烷、氯仿、四氢呋喃的平均回收率分别为97.2%

98.8%

102.5%

102.3%

100.3%

96.4%;相对标准偏差均不超过5.0%（n=6）。结论:该方法简单、准确、灵敏度高、重复性好

适用于酒石酸布托啡诺中的有机溶剂残留量的测定。

Abstract

Objective:To develop a headspace gas chromatography method for the residual organic solvents in butorphanol tartrate.Methods: The sample was injected into ZB-1 capillary column by headspace sampler and analysed with FID detector using ethylacetate as the internal standard and H

O as the solvent.Results: Methanol

acetone

dichloromethane

ether

chloroform

tetrahydrofuran were linear at the ranges of 1.811～394.6 μg·mL

-1

1.015～389.41

0.130～407.2

0.447～198.3.776～100.6

0.341～201.8 μg·mL

-1

respectively;The recoveries were 97.2%

98.8%

102.5%

102.3%

100.3%

96.4% respectively.Each of the relative standard deviations was no more than 5.0%.Conclusion: The method is simple

accurate and sensitive with good reproducibility.It can be used for the determination of the residual organic solvents in butorphanol tartrate.

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