痰热清注射液的稳定性研究及其与氨基糖苷类药物的配伍观察

文友民; 杨小英; 马晓艳

doi:10.13422/j.cnki.syfjx.2010.01.045

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痰热清注射液的稳定性研究及其与氨基糖苷类药物的配伍观察

化学与分析 | 更新时间：2024-09-23

- 痰热清注射液的稳定性研究及其与氨基糖苷类药物的配伍观察
- Study on Stability of Tanreqing Injection and Observation of its Compatibility with Aminoglycosides
- 中国实验方剂学杂志 2010年16卷第1期页码：32-34
- 作者机构：
  
  宁夏医科大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.01.045
  中图分类号： R942
- 纸质出版日期：2010
- 稿件说明：
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[1]文友民,杨小英,马晓艳.痰热清注射液的稳定性研究及其与氨基糖苷类药物的配伍观察[J].中国实验方剂学杂志,2010,16(01):32-34.

WEN You-min, YANG Xiao-ying~, MA Xiao-yan. Study on Stability of Tanreqing Injection and Observation of its Compatibility with Aminoglycosides[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 32-34.
[1]文友民,杨小英,马晓艳.痰热清注射液的稳定性研究及其与氨基糖苷类药物的配伍观察[J].中国实验方剂学杂志,2010,16(01):32-34. DOI： 10.13422/j.cnki.syfjx.2010.01.045.

WEN You-min, YANG Xiao-ying~, MA Xiao-yan. Study on Stability of Tanreqing Injection and Observation of its Compatibility with Aminoglycosides[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 32-34. DOI： 10.13422/j.cnki.syfjx.2010.01.045.

摘要

目的:考察痰热清注射液的稳定性及其与氨基糖苷类的配伍。方法:利用光阻法测定痰热清注射液在5%葡萄糖注射液、10%葡萄糖注射液、0.9%氯化钠注射液、复方氯化钠注射液、5%葡萄糖氯化钠注射液中的不溶性微粒。采用高效液相色谱法测定痰热清注射液分别与5%葡萄糖注射液、0.9%氯化钠注射液配伍放置8 h内

配伍液中黄芩苷含量的变化

并比较配伍前、后pH的变化。模拟临床条件观察庆大霉素、异帕米星、依替米星与痰热清配伍后的情况。结果:痰热清注射液与上述5种输液配伍后

微粒数均有所增加。其中与5%葡萄糖注射液、0.9%氯化钠注射液配伍后pH和黄芩苷含量无显著性变化。痰热清注射液与氨基糖苷类配伍后均有可见物生成。结论:痰热清注射液在临床输液中应注意不溶性微粒。痰热清与氨基糖苷类存在配伍禁忌。

Abstract

Objective:To investigate the stability of Tanreqing injection and its compatibility with Aminoglycosides.Methods: The insoluble particles of Tanreqing injection in five kinds of infusion solution were detected respectively by light-blockage method.The contents of Baicalin in two mixed solutions within 8h were determined by HPLC respectively.And the appearance and pH value of the mixtures were compared with those before mixing.The changes after Tanreqing injection mixed with isepamicin

etimicin or gentamycin were observed.Results: After Tanreqing injection was mixed with each one of the five kinds of infusion solution

the number of particles increased.And the contents of Baicalin and pH value had no obvious change in the solution mixed with 5% GS or 0.9% NS.There are visible substances in Tanreqing injection mixed with aminoglycosides.Conclusions: The insoluble particles of Tanreqing injection should be monitored in clinical application.There is incompatibility between Tanreqing injection and aminoglycosides.

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