DUAN Xiao-ying1, YAN Yan-cang2, GAO Wei-fang2, et al. Study on molding technics of Rujining capsule[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 4-6.
DUAN Xiao-ying1, YAN Yan-cang2, GAO Wei-fang2, et al. Study on molding technics of Rujining capsule[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 4-6. DOI: 10.13422/j.cnki.syfjx.2010.04.017.
乳疾宁胶囊成型工艺研究
摘要
目的:研究乳疾宁胶囊的成型工艺。方法:考察不同辅料对浸膏粉吸湿性的影响;以颗粒的合格率作为指标
筛选最佳制粒成型工艺条件
并考察颗粒的临界相对湿度
休止角及堆密度。结果:微晶纤维素为辅料抗湿性能较好
浸膏粉与辅料按7∶3的比例混匀
加入95%乙醇0.25倍制软材;制得颗粒流动性较好
临界相对湿度为50%
堆密度为0.466 g.mL-1。结论:该成型工艺合理、可行
为大生产提供了科学依据。
Abstract
Objective:To study the formation technology of Rujining capsule.Methods: The influence of different excipients on the hygroscopicity of extract powder was investigated by screening the best processing technol-ogy conditions and inspecting the critical relative humidity
angle of repose
and bulk density.Result: Microcrys-talline cellulose as excipients had a good anti-wet performance
the extract powder and microcrystalline cellulose were mixed evenly in proportion of 7∶ 3
the 95% alcohol was used as the weting agent
its amount was 25% of ex-tract powder.The granules of end product had a good fluidity
the critical relative humidity was about 50%
bulk density was 0.466 g.mL-1.Conclusion: The molding technology is reasonable