Objective:To research the effect of Lianqi Xiaoke Capsule on type 2 diabetic rats.Method: Type 2 diabetic rat model wase induced with high sucrose-fat diet for 4 weeks and streptozotocin ip for 30 mg.kg-1

all animals were grouped and administrated with drugs for 8 weeks.The fasting blood glucose

insulin

insulin sensitivity index

total cholesterol

triglyceride

superoxide dismutase and malondialdehyde were assessed and pancreatic pathological changes were observed.Result: ① model group vs normal control group: the fasting blood glucose

total cholesterol

triglyceride

malondialdehyde were obviously increased（P < 0.05

P < 0.01）

otherwise insulin

insulin sensitivity index

superoxide dismutase decreased（P < 0.05）

pancreatic damage were appeared;② Lianqi Xiaoke Capsule treatment groups vs.model group: the fasting blood glucose

total cholesterol

triglyceride

malondialdehyde were significantly decreased（P < 0.05

P < 0.01）

and insulin

insulin sensitivity index

superoxide dismutase increased（P < 0.05）

pancreatic damage were ameliorated.Conclusion: Lianqi Xiaoke Capsule could decrease fasting blood glucose and blood lipids via ameliorating pancreatic damage and insulin resistance

and inhibition of oxidative stress.