Objective:To investigate the effect of Ge Pi decoction on regulation of monocyte chemoattractant protein-1（MCP-1）level to reverse early diabetic nephropathy（DN）.Method: STZ diabetes model were induced by high lipoids and high glucose diet combined with intraperitoneal injection of small dose streptozotocin（STZ）（n = 41）.STZ-induced diabetes model of Wistar male rats were divided into the control group（n = 14）

the Traditional Chinese medicine（Ge Pi Decoction） treatment group（n = 13）

and the western medicine（benazepril） treatment group（n = 14）.After 8 weeks

detection of each group were carried out about weight

kidney weight index

blood glucose

urinary albumin microdosis

urinary albumin

blood and urine MCP-1

8-iso-prostaglandin F2a（8-iso-PGF2α）and tumor necrosis factor-α（TNF-α）

and oservation were performed on the pathological change of the rats renal with light microscope.Result: Compared with those in the control group

the body weight and kidney weight index were decreased in the Ge Pi Decoction treatment（P < 0.05）.Microdosis urin-albumin

MCP-1

8-iso-PGF2α and TNF were decreased significantly（P < 0.01）.There was no significant difference between Ge Pi Decoction treatment group and benazepril treatment group（P > 0.05）.In addition

there were positive correlation between 8-iso-PGF2α

MCP-1

TNF-α and UAER in each group.Ge Pi Decoction can relieve kidney hypertrophy

mesangial matrix hyperplasia and sclerosis.Conclusion: There are autoimmunity inflammation and oxidative stress in diabetic nephropathy.Ge Pi Decoction can inhibit various inflammatory factors in diabetic nephropathy.