Objective:To evaluate the effectiveness of ShuYu Capsule in patients with vascular depresion （VD）. Method: The investigational drugs were packed by blind method. A randomized

double-blind and controlled trial was conducted on sixty patients with VD. The sixty patients were randomly divided into treatment group （n = 30）

orally ShuYu Capsule 3# tid and Fluoxetine capsule placebo 20mg qd

for 8 wk. and control group （n = 30）

orally Fluoxetine capsule 20mg qd

and ShuYu Capsule placebo 3 # tid

for 8 wk. All subjects were assessed by HAMD

MMSE

CGI

NDS and Blood lipids. Result: ShuYu Capsule can be reduced the scores of HAMD

MMSE

CGI of Before and after treatment

The difference has statistics meaning （ P < 0. 05） between two groups; Can reduce the NDS grading and blood LDL-C level （ P < 0. 05） after 8 w in treatment group

But NDS grade and the blood LDL-C level can not be improved obviously （ P > 0. 05） in control group. Have not statistics significantly （ P > 0. 05 ） in the always efficient comparative difference between two groups of treatment. Conclusion: ShuYu Capsule has better clinical effect in vascular depresion

equal effect to Fluoxetine capsule.