Objective:To observe the influence of PRD（Pu Ren Dan） ultramicro-powder on the functional indexes correlated with glycometabolism in T2DM rats

including plasma glucose

glucose tolerance

glycosylated serum protein

serum insulin and insulin sensitivity index. And to investigate the hypoglycemic effect of PRD. Method: Wistar rats were fed fat milk

and small doses of streptozotocin was rapidly injected into tail vein. Animal models of type 2 diabetes with macroangiopathy characterized by insulin resistance were successfully prepared in a short time. The model rats were randomly divided into five groups including PRD low dose

PRD medium dose

PRD high dose

rosiglitazone maleate and model groups. Every group was respectively treated for 4 weeks with PRD low dose

PRD medium dose

PRD high dose

rosiglitazone maleate and water. Random plasma glucose of rats were respectively measured before treatment

after 2 weeks and 4 weeks with treatment. Fasting serum insulin and glycosylated serum protein content of rats were measured on the 4th weekend. And Insulin sensitivity index were calculated. Result:As compared with normal group rats

random plasma glucose and glycosylated serum protein content of model group rats were increased

while serum insulin and insulin sensitivity index significantly were decreased（P < 0. 01）. Random plasma glucose and glycosylated serum protein content of rats were all significantly reduced in PRD low

medium

high dose and rosiglitazone maleate groups （ P < 0. 05 ～ 0. 01 ）. Serum insulin content and insulin sensitivity index of T2DM model rats treated by PRD medium

high dose and rosiglitazone maleate were significantly increased（ P < 0. 05 ～ 0. 01）. Conclusion:Based on reducing the high level of plasma glucose and glycosylated serum protein content

PRD ultramicro-powder can enhance insulin sensitivity of T2DM rats and improve glycometabolism in T2DM rats.