Objective:To prepare compound Danshen pellets. Method: The compound Danshen pellets were prepared by using a centrifugal granulator. The composition and process factors were optimized by adopting several indices such as sphericity of pellets

repose angle

bulk density and friability. Result: The optimal process parameters were as follows:the quality ratio of Borneol-β-Cyclodextrinclusion Complexes and MCC was 4∶ 3

binder solvent was 40% syrup

which including extractive. The rotating rate of plate was 200 r·min -1

the blower rate was 8L·min -1

the rate of air flow was 18 L·min -1

the spray air pressure was 0. 06 MPa

the rotating rate of spray solution pump was 12 ～ 17 r·min -1 and the rotating rate of powder feed machine was 15 ～ 20 r·min -1. The active components could release more than 85% in 15 minutes. Conclusion: Under the optimal conditions

the compound Danshen pellets prepared by using the centrifugal granulator have prefect shape and surface characteristics

the yield of target size pellets are more than 85% . The three index components could release fast and synchronically.