表没食子儿茶素没食子酸酯对脊髓损伤大鼠炎症因子释放及神经营养因子表达的影响

邓凤君; 杨迎暴; 徐江平; 周丹; 李茹冰

doi:10.13422/j.cnki.syfjx.2010.05.056

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表没食子儿茶素没食子酸酯对脊髓损伤大鼠炎症因子释放及神经营养因子表达的影响

药理 | 更新时间：2024-09-23

- 表没食子儿茶素没食子酸酯对脊髓损伤大鼠炎症因子释放及神经营养因子表达的影响
- Effect of Epigaloctechin-3-gallit （EGCG） on the Release of Inflammatory Cytokines and Expression of Neurotrophic Factors in Spinal Cord-injuried Rats
- 中国实验方剂学杂志 2010年16卷第5期页码：195-198
- 作者机构：
  
  南方医科大学药学院药理学系
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.05.056
  中图分类号： R285.5
- 纸质出版日期：2010
- 稿件说明：
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[1]邓凤君,杨迎暴,徐江平,周丹,李茹冰.表没食子儿茶素没食子酸酯对脊髓损伤大鼠炎症因子释放及神经营养因子表达的影响[J].中国实验方剂学杂志,2010,16(05):195-198.

DENG Fun-jun, YANG Ying-bao, XU Jiang-ping, et al. Effect of Epigaloctechin-3-gallit （EGCG） on the Release of Inflammatory Cytokines and Expression of Neurotrophic Factors in Spinal Cord-injuried Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 195-198.
[1]邓凤君,杨迎暴,徐江平,周丹,李茹冰.表没食子儿茶素没食子酸酯对脊髓损伤大鼠炎症因子释放及神经营养因子表达的影响[J].中国实验方剂学杂志,2010,16(05):195-198. DOI： 10.13422/j.cnki.syfjx.2010.05.056.

DENG Fun-jun, YANG Ying-bao, XU Jiang-ping, et al. Effect of Epigaloctechin-3-gallit （EGCG） on the Release of Inflammatory Cytokines and Expression of Neurotrophic Factors in Spinal Cord-injuried Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 195-198. DOI： 10.13422/j.cnki.syfjx.2010.05.056.

摘要

目的:研究表没食子儿茶素没食子酸酯（epigaloctechin-3-gallit

EGCG）对脊髓损伤（spinal cord injury

SCI）大鼠炎症因子的释放及神经营养因子表达的影响。方法:建立大鼠脊髓半切SCI模型。SCI大鼠给予EGCG治疗24h后取血清和受损伤脊髓局部组织。ELISA法测定血清白介素-6（IL-6）、白介素-8（IL-8）含量;Westernblot法测定脊髓组织neurotrophin-3（NT-3）、brain-derived neurotrophic factor（BDNF）蛋白表达。结果:与模型组比较

EGCG能显著降低SCI大鼠血清炎性因子IL-6、IL-8的浓度

促进脊髓组织内源性NT-3、BDNF表达。结论:EGCG可抑制炎症因子释放

增加内源性神经营养因子表达。[关键词]脊髓损伤;表没食子儿茶素没食子酸酯;白介素-6;白介素-8;神经营养因子-3;脑源性神经营养因子

Abstract

Objective:To investigate the the protective effects of Epigallocatechin-3-gallate（EGCG） on the release of inflammatory cytokines and expression of neurotrophic factors in spinal cord-injuried（SCI） rats. Method: SCI model was reproduced by hemisection

and EGCG was administered for 24 h after hemisection 5 min after SCI. The concentrations of serum IL-6 and IL-8 were measured by ELISA assay

and the expression of neurotrophin-3 （NT-3） and brain-derived neurotrophic factor（BDNF） protein in injured spinal cord tissues were determined by western blot. Result: EGCG significantly reduced the levels of serum IL-6 and IL-8

and increased expression of NT-3 and BDNF at the injured spinal cord in SCI rats. Conclusion: EGCG may protect against spinal cord from injury by inhibiting release of inflammatory cytokines and enhancing the expression of endogenous neurotrophic factors in SCI rats.

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