JIA Xin, FENG Yong, GENG Fei, et al. Effect of Puwei Pill on Anti-oxidation and Improvement of Gastric Mucosal Blood Flow in Rats with Gastric Ulcer Recurrence[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 183-186.
JIA Xin, FENG Yong, GENG Fei, et al. Effect of Puwei Pill on Anti-oxidation and Improvement of Gastric Mucosal Blood Flow in Rats with Gastric Ulcer Recurrence[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 183-186. DOI: 10.13422/j.cnki.syfjx.2010.05.072.
Objective:To study the effect of Puwei Pill(PWP) on the anti-oxidation and improvement of the gastric mucosal blood flow in the rats with gastric ulcer recurrence. Method:The gastric ulcer recurrence model was developed by intraperitoneal injection with interleukin-1β ( IL-1β ). Then the pathohistological structure in the recurred gastric ulcer
treated by PWP ( ig
90 d)
was observed. The superoxide dismutase ( SOD)
nitric oxide (NO)
malondialdehyde(MDA) and endothelin-1 (ET-1) in the plasma and ET-1A expressed in the gastric mucosa were determined. Result: PWP could significantly resist the recurrence of gastric ulcer
increase the SOD
NO activity and decrease the contents of MDA and ET-1 in plasma. At the same time
PWP could significantly inhibit the ET-1A expression in the gastric mucosa. Conclusion:PWP can prevent the recurrence of the gastric ulcer
which mechanism is probably related to the increase of anti-oxidation capacity and improvement of mucosal blood flow.