Objective:To explore the preventive and therapeutic effects of Qingyi granule on the lung injury induced by severe acute pancreatitis（SAP）.Method:SAP consists of 58 patients with combination therapy group（n = 32）and conventional western medicine treatment group（n = 26）.The two groups were observed in patients with abdominal pain and ease the time

peristaltic recovery time

time to correct hypoxemia

treatment before and 72 h after treatment of blood endotoxin（ET）

tumor necrosis factor-α（TNF-α）

interleukin-6（IL-6） levels of change and re-line upper abdominal spiral CT scan assessment of the progress of pancreatitis patients.Result:The combination therapy group treated with conventional Western medicine incidence of hypoxemia were 43.75%

76.92%（P < 0.05）;ARDS incidence rate of 9.38%

respectively

34.62%（P < 0.05）;treatment 72 h after the combination therapy group of blood ET

TNF-α

IL-6 than conventional western medicine treatment group blood ET

TNF-α

IL-6 levels were significantly decreased（P < 0.05）;in the combination therapy group the time to ease abdominal pain

bowel recovery time

hypoxemia corrected time

CT scan shows the extent of progress of pancreatitis was significantly lower than the proportion of conventional western medicine treatment group（P < 0.05）.Conclusion:Qingyi particles through the protection of the intestinal barrier

reducing bacterial translocation

lower serum endotoxin

TNF-α

IL-6 and other inflammatory mediators

and correct the body imbalance between proinflammatory and anti-inflammatory system

and many other mechanisms of play a role in the comprehensive protection of the lungs.