乳香没药对大鼠肝脏毒性的比较研究

周昆; 谈英; 柳占彪; 张跃飞; 胡利民; 高秀梅

doi:10.13422/j.cnki.syfjx.2010.06.039

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乳香没药对大鼠肝脏毒性的比较研究

药理 | 更新时间：2024-09-23

- 乳香没药对大鼠肝脏毒性的比较研究
- Comparative Study on Hepatotoxicity of Olibanum and Myrrha in Rats
- 中国实验方剂学杂志 2010年16卷第6期页码：221-223
- 作者机构：
  
  1. 天津中医药大学中医药研究院天津市中药药理重点实验室
  2. 三九医药股份有限公司研发事业部
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.06.039
  中图分类号： R285.5
- 纸质出版日期：2010
- 稿件说明：
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[1]周昆,谈英,柳占彪,张跃飞,胡利民,高秀梅.乳香没药对大鼠肝脏毒性的比较研究[J].中国实验方剂学杂志,2010,16(06):221-223.

ZHOU Kun1, TAN Ying2, LIU Zhan-biao1, et al. Comparative Study on Hepatotoxicity of Olibanum and Myrrha in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 221-223.
[1]周昆,谈英,柳占彪,张跃飞,胡利民,高秀梅.乳香没药对大鼠肝脏毒性的比较研究[J].中国实验方剂学杂志,2010,16(06):221-223. DOI： 10.13422/j.cnki.syfjx.2010.06.039.

ZHOU Kun1, TAN Ying2, LIU Zhan-biao1, et al. Comparative Study on Hepatotoxicity of Olibanum and Myrrha in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 221-223. DOI： 10.13422/j.cnki.syfjx.2010.06.039.

摘要

目的:比较乳香和没药对大鼠的肝脏毒性。方法:48只Wistar大鼠随机分为4组

分别为对照组、乳香没药（1∶1）组、乳香组、没药组

各给药组剂量均为2.1 g.kg-1

连续ig 12周。禁食12 h后水合氯醛麻醉动物

取血检测血清生化指标

并解剖称取肝脏湿重计算肝脏系数

并测定肝组织中MDA含量

光镜下对肝脏进行病理组织学检查。结果:乳香没药组和乳香组大鼠的血清总胆固醇（TC）和肝组织中丙二醛（MDA）明显高于对照组（P<0.05）。给药组大鼠肝系数均明显升高（P<0.01）

肝系数乳香组>乳香没药组>没药组。肝脏病理组织学检查表明

乳香组2只大鼠肝脏中度脂肪变性

而乳香没药组和没药组则未见明显异常。结论:乳香对大鼠的肝脏毒性强于没药。

Abstract

Objective:To compare hepatotoxicity of Olibanum and Myrrha.Method:48 Wistar rats were divided into four groups by random.3 groups were intragastrically treated with Olibanum + Myrrha

Olibanum

Myrrha that doses were all 2.1 g.kg-1 once a day for 12 weeks and the control group with water.The animals were anesthesia by chloral hydrate after fasting for 12 hours and serum biochemical indices were determined.Liver was weighted and liver coefficient was calculated

and MDA in liver tissue was determined.Histopathological examination for the liver was also performed with lightmicroscope.Result:TC in serum and MDA in liver tissue of the animals with Olibanumhe + Myrrha and Olibanumhe increased significantly compared with animials of control group.The liver coefficients of all groups administrated were significiantly higher than that of control group

which was Olibanum > Olibanum + Myrrha > Myrrha.Histopathologic examination showed that 2 rats of the Olibanum group had fatty degeneration in liver but the animals of other groups didn’t.Conclusion:Hepatotoxicity of Olibanum was higher than Myrrha in rats.

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