Objective:To study the influence of Huangqi Guizhi Wuwu Decoction（Hw） on hemorheological indexes in rats with chilblains.Method:Rat chilblains model was established through soaking rats’ feet in low temperature 40% alcohol solution.The contents of TXB2 and 6-k-PGF1α in plasma of the rats taken by Hw through different ways such as oral administration

the immersion

and the oral administration + soak（IS） were determined.Result:Compared with the normal control group

blood viscosity

blood plasma viscosity

index of RBC aggragation and index of deformation in rats of model group were significantly increased（P < 0.05）

TXB2 were significantly increased（P < 0.05） and 6-k-PGF1α decreased（P < 0.01）.Compared with the rats of model group

TXB2 decreased（P < 0.05） significantly in plasma of the rats with the Hw taken by the IS;PGF1αincreased（P < 0.05 or P < 0.01） in plasma of the rats with the Hw taken by the oral administration and the IS.The Hw groups taken by different ways had improved hemorheological indexes to varying degrees.Conclusion:The model of chilblains brings about the unbalance of immunological function

microcycle barrier and a state of forming thrombus easily.The Hw groups taken by different ways can adjust the abnormal changes in immunology

the unbalance of TXA2-PGI2 and improve blood rheology targets

and the group of Hw taken by the IS is better than those of the other two Hw groups.