六味地黄丸对自发乳腺癌小鼠瘤块中血管内皮生长因子和周期蛋白D3基因表达的影响

郑里翔; 刘红宁; 乔玉丹; 刘霞; 林栋美

doi:10.13422/j.cnki.syfjx.2010.11.040

您当前的位置：

首页 >

文章列表页 >

六味地黄丸对自发乳腺癌小鼠瘤块中血管内皮生长因子和周期蛋白D3基因表达的影响

药理 | 更新时间：2024-09-23

- 六味地黄丸对自发乳腺癌小鼠瘤块中血管内皮生长因子和周期蛋白D3基因表达的影响
- Effect of Liuwei Dihuang Wan on Vascular Endothelial Grouth Factor Expression and Cyclin D3 Gene in Spontaneous Breast Carcinoma in Mice
- 中国实验方剂学杂志 2010年16卷第11期页码：117-119
- 作者机构：
  
  江西中医学院
- 作者简介：
- 基金信息：
  
  江西省自然科学基金资助（2008GZY0007）;江西省教育厅基金项目（GJJ10528）
- DOI：10.13422/j.cnki.syfjx.2010.11.040
  中图分类号： R285.5
- 纸质出版日期：2010
- 稿件说明：
移动端阅览
[1]郑里翔,刘红宁,乔玉丹,刘霞,林栋美.六味地黄丸对自发乳腺癌小鼠瘤块中血管内皮生长因子和周期蛋白D3基因表达的影响[J].中国实验方剂学杂志,2010,16(11):117-119.

ZHENG Li-xiang, LIU Hong-ning, QIAO Yu-dan, et al. Effect of Liuwei Dihuang Wan on Vascular Endothelial Grouth Factor Expression and Cyclin D3 Gene in Spontaneous Breast Carcinoma in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 117-119.
[1]郑里翔,刘红宁,乔玉丹,刘霞,林栋美.六味地黄丸对自发乳腺癌小鼠瘤块中血管内皮生长因子和周期蛋白D3基因表达的影响[J].中国实验方剂学杂志,2010,16(11):117-119. DOI： 10.13422/j.cnki.syfjx.2010.11.040.

ZHENG Li-xiang, LIU Hong-ning, QIAO Yu-dan, et al. Effect of Liuwei Dihuang Wan on Vascular Endothelial Grouth Factor Expression and Cyclin D3 Gene in Spontaneous Breast Carcinoma in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 117-119. DOI： 10.13422/j.cnki.syfjx.2010.11.040.

摘要

目的:探讨六味地黄丸对小鼠自发乳腺癌的影响。方法:以清洁级昆明小鼠雌性种鼠自发乳腺癌为模型

用六味地黄丸治疗直至濒死期

瘤块病理分析用HE染色

血管内皮生长因子（VEGF）和周期蛋白D3（cyclin D3）基因表达的产物用RT-PCR及Western bloting方法。结果:六味地黄丸组的瘤组织分化优于对照组

瘤重明显低于对照组（P<0.05）

瘤块中VEGF和cyclin D3基因表达产物也明显低于对照组（P<0.05）。结论:六味地黄丸抑制乳腺癌的生长

促进细胞分化

可能的机制是抑制VEGF和cyclin D3基因表达。ds

Abstract

Objective:To investigate the effect of Liuwei Dihuang Wan on spontaneous breast carcinoma in mice.Method:The spontaneous breast carcinoma derived in kunming mice（clean class） was used as animal model.The mice were given Liuwei Dihuang Wan to their agonal stage.The cancer mass pathology was analyzed by HE staining.The mRNA and protein expressions of vascular endothelial growth factor（VEGF） and cyclin D3 were assayed by RT-PCR and Western blotting.Result:In Liuwei Dihuang Wan group

the tumor weight and expression of VEGF and cyclin D3 gene were obviously lower than that in the control groups（P < 0.05）.The cell differentiation was also better than that in the control group.Conclusion:Liuwei Dihuang Wan can retrain the growth of cancer and promote the cancer cell differentiation.The possible mechanism is related with the retrained expression of VEGF and cyclin D3 gene.

关键词

Keywords

references

浏览量

321

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

六味地黄丸对自发乳腺癌小鼠瘤块中血管内皮生长因子和周期蛋白D3基因表达的影响

补肾调肝周期疗法及组方通过miR-140-5P/VEGF通路改善多囊卵巢综合征大鼠“着床窗口期”子宫内膜容受性机制

基于JAK2/STAT3通路介导的星形胶质细胞A1/A2表型转化探讨桃红四物汤对脑缺血再灌注损伤的保护作用

小陷胸汤对5-FU介导小鼠心肌纤维化及HIF-1α/VEGF信号通路蛋白表达的影响

秦艽、威灵仙组分配伍对类风湿关节炎模型大鼠血清炎症因子及踝关节NF-κB、VEGF表达的影响