WANG Yan, MA Chun-jie, SONG Mei-dan, et al. Effect of Weihe Ⅱ Powder on Pathomorphological Changes and Anti-oxidative Activities in Rats with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 129-131.
WANG Yan, MA Chun-jie, SONG Mei-dan, et al. Effect of Weihe Ⅱ Powder on Pathomorphological Changes and Anti-oxidative Activities in Rats with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 129-131. DOI: 10.13422/j.cnki.syfjx.2010.12.038.
Objective: To study the effect and the mechanism of Weihe Ⅱ Powder on rats with chronic atrophic gastritis(CAG).Method: Chronic atrophic gastritis of rat was established through a synthesized method.The rats were treated with Weihe Ⅱ Powder after the model was made successfully.The influences of the powder on morphology of gastric mucosa and anti-oxidative enzyme activities in serum of the rats with CAG were investigated.Result: Weihe Ⅱ Powder could reduce the injuries in CAG rats
increase the thickness of mucosa glandular(P < 0.01) to restore the gastric mucosa
reduce inflammatory reactions
enhance activities of SOD and GSH-Px
decrease content of MDA(P < 0.05).Conclusion: Weihe Ⅱ Powder could improve pathomorphological changes in CAG rats.It might be related with enhancement of anti-oxidative enzyme activities to avoid injuries induced by free radicals.