Objective: To evaluate the efficacy and safety of nourishing Blood and strengthening qi

a traditional Chinese medicine（TCM） therapy

combined with anti-hestamine drugs for the treatment of chronic idiopathic uticaria（CIU）.Method: Seventy five cases were allocated randomly into a experiment group and a control one.Yuping Fengsan and Taohong Siwu Tang

two famous TCM decoctions representing the therapy

combined with Cetirizine Hydrochloride Tablets were given to the experiment group.Cetirizine Hydrochloride Tablets were solely issued to the control group.The duration of administration for both groups was 30 days.The symptom grades at the point of the 0

5th

10th

15th

20th

25th

and 30th day and the efficacy rate after the 30 days administration were calculated.In addition

a 2-month follow-up towards the recovered cases was carried out.Result: The experiment group had better improvement on symptom grades than that of the controls along with the administration duration.For recovery rate

experiment group also had evident preponderance to controlled（P < 0.05）.The difference of general efficacy rate between two groups had no statistical significance.Combining TCM therapy also had a lower recurrence rate than that of applying sole western medicine（P < 0.05）.Both group showed no severe adverse effect during the trial.Conclusion: The nourishing blood and strengthening qi therapy in TCM combined with anti-hestamine drugs can help improving and stabilizing the efficacy when treating CIU.