三黄益肾胶囊对糖尿病大鼠肾脏转化生长因子β1及血管内皮生长因子表达的影响

迟秀娥; 王元松; 田风胜; 苏秀海; 李文东; 王晓蕴; 屈会云

doi:10.13422/j.cnki.syfjx.2010.14.059

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三黄益肾胶囊对糖尿病大鼠肾脏转化生长因子β1及血管内皮生长因子表达的影响

药理 | 更新时间：2024-09-23

- 三黄益肾胶囊对糖尿病大鼠肾脏转化生长因子β1及血管内皮生长因子表达的影响
- Effects of Sanhuang Yishen Capsule on Expression of TGF-β1 and VEGF in Kidney of Diabetic Rats
- 中国实验方剂学杂志 2010年16卷第14期页码：143-146
- 作者机构：
  
  河北医科大学附属沧州中西医结合医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.14.059
  中图分类号： R285.5
- 纸质出版日期：2010
- 稿件说明：
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[1]迟秀娥,王元松,田风胜,苏秀海,李文东,王晓蕴,屈会云.三黄益肾胶囊对糖尿病大鼠肾脏转化生长因子β1及血管内皮生长因子表达的影响[J].中国实验方剂学杂志,2010,16(14):143-146.

CHI Xiu-e, WANG Yuan-song, TIAN Feng-sheng, et al. Effects of Sanhuang Yishen Capsule on Expression of TGF-β1 and VEGF in Kidney of Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 143-146.
[1]迟秀娥,王元松,田风胜,苏秀海,李文东,王晓蕴,屈会云.三黄益肾胶囊对糖尿病大鼠肾脏转化生长因子β1及血管内皮生长因子表达的影响[J].中国实验方剂学杂志,2010,16(14):143-146. DOI： 10.13422/j.cnki.syfjx.2010.14.059.

CHI Xiu-e, WANG Yuan-song, TIAN Feng-sheng, et al. Effects of Sanhuang Yishen Capsule on Expression of TGF-β1 and VEGF in Kidney of Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 143-146. DOI： 10.13422/j.cnki.syfjx.2010.14.059.

摘要

目的:观察经验方三黄益肾胶囊对糖尿病早期肾病大鼠的干预作用

探讨其可能的作用机制

为临床防治糖尿病肾病提供可靠的实验依据。方法:糖尿病模型大鼠随机分为4组:模型对照组、三黄益肾低剂量治疗组（0.4 g.kg-1.d-1）、中剂量治疗组（0.8 g.kg-1.d-1）、高剂量治疗组（1.6 g.kg-1.d-1）。另设一组正常对照组。三黄益肾胶囊治疗8周末

观察各组血糖、糖化血红蛋白、肌酐、尿素氮、胆固醇、甘油三酯水平及肾重/体重指数（肾重/体重比值×1000）。采用免疫组化法检测大鼠肾组织中转化生长因子β1（TGF-β1）

血管内皮生长因子（VEGF）的表达。结果:经治疗8周后

三黄益肾中、高剂量治疗组与糖尿病模型对照组比较

肾重/体重比值明显减少（P<0.01）;血清肌酐、尿素氮水平明显降低（P<0.01）。肾组织中TGF-β1及VEGF表达低于糖尿病模型对照组（P<0.05）。结论:三黄益肾胶囊能够降低TGF-β1

VEGF在肾脏的表达水平

延缓糖尿病大鼠的肾损伤。

Abstract

Objective:To observe and verify the intervention action of Sanhuang Yishen Capsule in rats with early diabetic nephropathy

and to study its possible mechanism

so as to provide experimental evidence for the clinic prevention of diabetic nephropathy.Method:Diabetic rats（n = 13/group） were randomly divided into diabetes model group

low-dose Sanhuang Yishen Capsule treated group（0.4 g.kg-1.d-1）

middle-dose Sanhuang Yishen Capsule treated group（0.8 g.kg-1.d-1）

high-dose Sanhuang Yishen Capsule treated group（1.6 g.kg-1.d-1）.Ten SD rats were selected as control group.At the end of the 8th week

we detected blood glucose

glycosylated hemoglobin

creatinine

urea nitrogen

triglyceride

cholesterol and kidney weight/body weight index.The expression of renal TGF-β1 and VEGF were assessed by immune-histochemistry.Result:After treatment of 8 weeks

compared with the diabetes model group the middle-dose and the high-dose Sanhuang Yishen Capsule groups showed obviously decreases in kidney weight/body weight index and the level of serum creatinine

urea nitrogen（P < 0.01）.The expression of TGF-β1 and VEGF in kidney of middle-

high-dose Sanhuang Yishen Capsule treated group rats was lower than that of the diabetes model group（P < 0.05）.Conclusion:Sanhuang Yishen Capsule can reduce the expression of TGF-β1 and VEGF in the kidney of diabetic rats and delay of renal injury in diabetic rats.

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三黄益肾胶囊对糖尿病大鼠肾脏转化生长因子1及血管内皮生长因子表达的影响