脂康口崩片的制剂处方筛选及大黄素、大黄酚的含量测定

杜倩; 宋亚玲; 陶柏成; 张海霞; 高彩云

doi:10.13422/j.cnki.syfjx.2010.15.009

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脂康口崩片的制剂处方筛选及大黄素、大黄酚的含量测定

工艺与制剂 | 更新时间：2024-09-23

- 脂康口崩片的制剂处方筛选及大黄素、大黄酚的含量测定
- Formula Optimization of Zhikang Orally Disintegrating Tablets and Assay of Emodin and Chrysophanol in the Tablets
- 中国实验方剂学杂志 2010年16卷第15期页码：24-27
- 作者机构：
  
  徐州医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.15.009
  中图分类号： R286.0
- 纸质出版日期：2010
- 稿件说明：
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[1]杜倩,宋亚玲,陶柏成,张海霞,高彩云.脂康口崩片的制剂处方筛选及大黄素、大黄酚的含量测定[J].中国实验方剂学杂志,2010,16(15):24-27.

DU Qian, SONG Ya-ling, TAO Bai-cheng, et al. Formula Optimization of Zhikang Orally Disintegrating Tablets and Assay of Emodin and Chrysophanol in the Tablets[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 24-27.
[1]杜倩,宋亚玲,陶柏成,张海霞,高彩云.脂康口崩片的制剂处方筛选及大黄素、大黄酚的含量测定[J].中国实验方剂学杂志,2010,16(15):24-27. DOI： 10.13422/j.cnki.syfjx.2010.15.009.

DU Qian, SONG Ya-ling, TAO Bai-cheng, et al. Formula Optimization of Zhikang Orally Disintegrating Tablets and Assay of Emodin and Chrysophanol in the Tablets[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 24-27. DOI： 10.13422/j.cnki.syfjx.2010.15.009.

摘要

目的:筛选脂康口崩片的制剂处方和成型工艺

建立制剂中大黄素及大黄酚含量测定的HPLC法。方法:以成型性、崩解时限和口感为指标

采用平行设计法筛选最佳处方。采用HPLC测定制剂中大黄素和大黄酚的含量

流动相甲醇-0.2%甲酸（82∶18）;检测波长254 nm;柱温35℃;流速1.0 mL·min-1。结果:经最佳制备工艺制得的脂康口崩片外观及口感良好

在1 min内能崩解完全。HPLC测定大黄素及大黄酚分别在0.100 5～0.201 0μg

0.040 2～1.608 0μg线性关系良好

平均回收率分别为99.44%和98.18%。结论:脂康口崩片组方合理

制备工艺可行

建立的含量测定方法简便、准确

专属性好。

Abstract

Objective: To optimize the formulation and preparation process of Zhi-kang orally disintegrating tablets

and establish an HPLC method for determination of emodin and chrysophanol in the tablets.Method:The prescription of Zhi-kang orally disintegrating tablets were optimized by parallel design technique

with disintegrating time

appearance and taste as the assessment index.The analytical column was packed with Kromasil C18（200 mm × 4.6 mm

5 μm） and performed at 35 ℃.The mobile phase was consisted of methanol-0.2% formic acid（82∶ 18）.The flow rate was 1.0 mL.min-1.Result:The tablets prepared were fine in appearance and taste

disintegrated within 1 min.Emodin and chrysophanol were linear in the range of 0.100 5-0.201 0 μg and 0.040 2-1.608 0 μg respectively.The average recovery was 99.44%（emodin） and 98.18%（chrysophanol）.Conclusion: The disintegrating tablets were designed rationally and feasible to operate.HPLC assay was simple

accurate and specific.

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